Immunological Synapses

Known as: supramolecular activation cluster, Synapses, Immunological, Immunological Synapse 
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
02040608019982018

Papers overview

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Highly Cited
2007
Highly Cited
2007
T helper (Th) cell activation is required for the adaptive immune response. Formation of the immunological synapse (IS) between… (More)
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Highly Cited
2006
Highly Cited
2006
Cytotoxic T lymphocytes (CTLs) destroy virally infected and tumorigenic cells by releasing the contents of specialized secretory… (More)
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Highly Cited
2005
Highly Cited
2005
The immunological synapse is a specialized cell-cell junction that is defined by large-scale spatial patterns of receptors and… (More)
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Highly Cited
2004
Highly Cited
2004
A notable feature of T lymphocyte recognition on other cell surfaces is the formation of a stable mature immunological synapse… (More)
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Highly Cited
2004
Highly Cited
2004
The reported affinity differences between CD28 and CTLA-4 binding to B7-1 and B7-2 may serve to selectively regulate CD28 and… (More)
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Highly Cited
2003
Highly Cited
2003
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is… (More)
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Highly Cited
2002
Highly Cited
2002
CD28 and CTLA-4 engagement with B7 expressed by APCs generates critical regulatory signals for T cell activation. CD28 is… (More)
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Highly Cited
2001
Highly Cited
2001
Cytotoxic T lymphocytes (CTL) rapidly destroy their targets. Here we show that although target cell death occurs within 5 min of… (More)
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Highly Cited
2001
Highly Cited
2001
According to the two-signal model of T cell activation, costimulatory molecules augment T cell receptor (TCR) signaling, whereas… (More)
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Highly Cited
1999
Highly Cited
1999
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central… (More)
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