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Multiple myeloma (MM) is an incurable plasma cell malignancy. The 26S proteasome inhibitor, bortezomib, selectively induces… Expand DURING their transit through the endoplasmic reticulum, newly synthesized light and heavy chains of immunoglobulins associate… Expand THE antigen receptors on mature B lymphocytes are membrane-bound immunoglobulins of the IgM and IgD classes1,2 whose cross… Expand COMPLEMENTARY DNAs derived from a mouse hybridoma messenger RNA were used to transform tobacco leaf segments followed by… Expand During the past several years, it has become increasingly evident that the regulation of immunoglobulin (Ig) gene assembly and… Expand The yeast Saccharomyces cerevisiae can synthesize, process and secrete higher eukaryotic proteins1–5. We have investigated the… Expand We have cloned and sequenced a human mRNA specific for mammalian T-lymphoid cells. The message was found to be expressed in human… Expand We have produced cell hybrids between mouse myeloma cells, which do not produce immunoglobulin chains, and Burkitt lymphoma cells… Expand Human immunoglobulin chains are expressed in somatic cell hybrids between mouse myeloma cells and human B cells1,2. By… Expand We have studied somatic cell hybrids between P3x63Ag8 mouse myeloma cells deficient in hypoxanthine phosphoribosyltransferase (EC… Expand