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Immunoglobulin Light Chains, Surrogate

Known as: Surrogate Light Chains, Immunoglobulin psiL Chain, Light Chains, Surrogate 
An immunolglobulin light chain-like protein composed of an IMMUNOGLOBULIN VARIABLE REGION-like peptide (such as light chain like lambda5 peptide) and… Expand
National Institutes of Health

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4 relations
In Bloodaspects of radiation effectsphysiological aspects

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Surrogate lambda Light Chain

Papers overview

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Highly Cited
2008
Highly Cited
2008
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
Induced pluripotent stem (iPS) cells have been generated from mouse and human fibroblasts by the retroviral transduction of four… Expand
Highly Cited
2008
Highly Cited
2008
Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development.
Pre-B lymphocytes consist of 2 distinct cell populations: large pre-B and small pre-B. The large pre-B cells are newly generated… Expand
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Highly Cited
2007
Highly Cited
2007
Coordinate and subspace optimization methods for linear least squares with non-quadratic regularization
Abstract This work addresses the problem of regularized linear least squares (RLS) with non-quadratic separable regularization… Expand
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Highly Cited
2002
Highly Cited
2002
Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering
Although preB cell-receptor (pre-BCR) formation and cell-surface expression is essential for B cell development, pre-BCR… Expand
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Highly Cited
1997
Highly Cited
1997
EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes.
Early B cell factor (EBF) and E47 participate in the transcriptional control of early B lymphocyte differentiation. With the aim… Expand
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Highly Cited
1996
Highly Cited
1996
Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.
Allelic exclusion at the IgH locus was examined in B lineage cells of wild-type mice and mice unable to express the surrogate… Expand
Highly Cited
1995
Highly Cited
1995
Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.
Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional… Expand
Review
1995
Review
1995
Positive and negative selection events during B lymphopoiesis.
Early in B-cell development, large numbers of cells have to be generated, each of which expresses only one type of B-cell… Expand
Highly Cited
1994
Highly Cited
1994
The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice
Precursor B (pre-B) cells in bone marrow of normal and B cell-deficient mutant mice were analyzed for the expression of Vpre-B… Expand
Review
1993
Review
1993
The surrogate light chain in B-cell development.
The proteins encoded by the VpreB and lambda 5 genes associate with each other to form a light (L) chain-like structure, the… Expand
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