Immortalization

Known as: Immortalized 
Laboratory methods used to generate cells that are able to reproduce indefinitely.

Topic mentions per year

Topic mentions per year

1979-2017
02040608019792017

Papers overview

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Highly Cited
2009
Highly Cited
2009
The overexpression of defined transcription factors in somatic cells results in their reprogramming into induced pluripotent stem… (More)
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Highly Cited
2008
Highly Cited
2008
Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a… (More)
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Highly Cited
2005
Highly Cited
2005
An unbiased screen for genes that can immortalize mouse embryonic fibroblasts identified the glycolytic enzyme phosphoglycerate… (More)
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Highly Cited
1997
Highly Cited
1997
Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal human somatic cells but is reactivated… (More)
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Highly Cited
1997
Highly Cited
1997
A subset of chromosomal translocations in acute leukemias results in the fusion of the trithorax-related protein HRX with a… (More)
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Highly Cited
1995
Highly Cited
1995
Immortalization of human cells is often associated with reactivation of telomerase, a ribonucleoprotein enzyme that adds TTAGGG… (More)
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Highly Cited
1995
Highly Cited
1995
A replication-defective recombinant retrovirus containing the human papilloma virus E6/E7 genes (LXSN-16 E6E7) was used to… (More)
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Highly Cited
1994
Highly Cited
1994
Immortalized human chondrocytes were established by transfection of primary cultures of juvenile costal chondrocytes with vectors… (More)
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Highly Cited
1994
Highly Cited
1994
PURPOSE To establish primary and immortalized cell cultures of human lens epithelial cells for a model system investigating human… (More)
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Highly Cited
1990
Highly Cited
1990
By genetically targeting tumorigenesis to specific hypothalamic neurons in transgenic mice using the promoter region of the… (More)
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