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Immortalization

Known as: Immortalized 
Laboratory methods used to generate cells that are able to reproduce indefinitely.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The epithelial-mesenchymal transition (EMT) is a key developmental program that is often activated during cancer invasion and… Expand
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Highly Cited
2008
Highly Cited
2008
Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a… Expand
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Highly Cited
2006
Highly Cited
2006
To direct human embryonic stem (HES) cells to a dopaminergic neuronal fate, we cocultured HES cells that were exposed to both… Expand
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Review
2005
Review
2005
Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells… Expand
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Highly Cited
1998
Highly Cited
1998
Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of… Expand
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Highly Cited
1998
Highly Cited
1998
Normal human cells undergo a limited number of divisions in culture and enter a non-dividing state called replicative senescence… Expand
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Highly Cited
1997
Highly Cited
1997
Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal human somatic cells but is reactivated… Expand
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Highly Cited
1992
Highly Cited
1992
The study of human microvascular endothelial cells has been limited, because these cells are difficult to isolate in pure culture… Expand
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Highly Cited
1990
Highly Cited
1990
Two sublines of a breast epithelial cell culture, MCF-10, derived from human fibrocystic mammary tissue exhibit immortality after… Expand
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Highly Cited
1988
Highly Cited
1988
In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization… Expand
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