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IkappaB kinase activity

Known as: inhibitor of NF-kappaB kinase activity, ATP:IkappaB protein phosphotransferase activity, IKK 
Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. [EC:2.7.11.10]
National Institutes of Health

Related topics

Related topics

5 relations
CHUK geneIkappaB kinaseInhibitor of Nuclear Factor Kappa-B Kinase Subunit Betaconserved helix-loop-helix ubiquitous kinase

Broader (1)

I-kappaB phosphorylation

Papers overview

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2014
2014
Targeting HER2+ breast cancer: the TBK1/IKKε axis
HER2+ breast cancer (BC) is a highly aggressive subtype, affecting ~20% of BC patients. Current treatments include adjuvant or… 
2013
2013
Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation.
NF-κB, which is activated by the inhibitor of NF-κB kinase (IKK), is involved in the progression of inflammatory disease. However… 
Review
2012
Review
2012
[Nucleic acids recognition by innate immunity].
The innate immune system detects pathogen-derived nucleic acids (DNA and RNA) and induces type I interferon (IFN) and other… 
2008
2008
Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK.
Type I interferons (IFNs) are critical mediators of the innate immune system to defend viral infection. Interferon regulatory… 
2004
2004
Regulation of α-Fetoprotein by Nuclear Factor-κB Protects Hepatocytes from Tumor Necrosis Factor-α Cytotoxicity during Fetal Liver Development and Hepatic Oncogenesis
Nuclear factor-κB (NF-κB) plays a critical role during fetal liver development and hepatic oncogenesis. Here, we have assessed… 
2002
2002
Measurement of IKK activity in primary rat T cells: rapid activation and inactivation.
2002
2002
Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.
Human T-cell leukemia virus type 1 oncoprotein Tax activates NF-kappaB through direct binding to IKK-gamma, the regulatory… 
2001
2001
5-Fluorouracil suppression of NF-KappaB is mediated by the inhibition of IKappab kinase activity in human salivary gland cancer cells.
We have recently shown that 5-Fluorouracil (5-FU) suppresses the transcription factor NF-kappaB in human salivary gland cancer… 
1999
1999
Assay for IkappaB kinases using an in vivo biotinylated IkappaB protein substrate.
IkappaB kinases (IKK)-1 and -2 are related kinases that are induced by stimuli such as TNF or IL-1 to phosphorylate serines 32… 
1995
1995
CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain.
We have identified a new member of the helix-loop-helix (H-L-H) and leucine zipper gene families via a reverse transcriptase… 
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