IkappaB kinase activity

Known as: inhibitor of NF-kappaB kinase activity, ATP:IkappaB protein phosphotransferase activity, IKK 
Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. [EC:2.7.11.10]

Topic mentions per year

Topic mentions per year

1997-2017
0204019972017

Papers overview

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Highly Cited
2009
Highly Cited
2009
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard… (More)
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Highly Cited
2008
Highly Cited
2008
Viral infection triggers activation of transcription factors such as NF-kappaB and IRF3, which collaborate to induce type I… (More)
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Highly Cited
2006
Highly Cited
2006
This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer pathophysiology by identifying… (More)
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Highly Cited
2004
Highly Cited
2004
Phosphorylation of NF-kappaB p65(RelA) serine 536 is physiologically induced in response to a variety of proinflammatory stimuli… (More)
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Highly Cited
2004
Highly Cited
2004
Viral infection and stimulation with lipopolysaccharide (LPS) or double stranded RNA (dsRNA) induce phosphorylation of interferon… (More)
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Highly Cited
2001
Highly Cited
2001
The sedative and anti-nausea drug thalidomide, which causes birth defects in humans, has been shown to have both anti… (More)
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Highly Cited
2001
Highly Cited
2001
The serine/threonine kinase Akt/PKB is a potent regulator of cell survival and has oncogenic transformation potential. Previously… (More)
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Highly Cited
2000
Highly Cited
2000
trans-Resveratrol (Res), a phytoalexin found at high levels in grapes and in grape products such as red wine, has been shown to… (More)
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Highly Cited
1999
Highly Cited
1999
IkappaB [inhibitor of nuclear factor kappaB (NF-kappaB)] kinase (IKK) phosphorylates IkappaB inhibitory proteins, causing their… (More)
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Highly Cited
1997
Highly Cited
1997
Activation of the transcription factor nuclear factor kappa B (NF-kappaB) is controlled by sequential phosphorylation… (More)
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