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IkappaB kinase activity

Known as: inhibitor of NF-kappaB kinase activity, ATP:IkappaB protein phosphotransferase activity, IKK 
Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. [EC:2.7.11.10]
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
New players in Lou Gehrig's disease Amyotrophic lateral sclerosis (ALS), often referred to as “Lou Gehrig's disease,” is a… Expand
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Highly Cited
2012
Highly Cited
2012
The adaptor protein STING recruits a kinase and a transcription factor to mediate responses to cytosolic DNA. Right Place and… Expand
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Highly Cited
2010
Highly Cited
2010
The innate immune system detects pathogen- and host-derived double-stranded DNA exposed to the cytosol and induces type I… Expand
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Highly Cited
2009
Highly Cited
2009
Cell-autonomous innate immune responses against bacteria attempting to colonize the cytosol of mammalian cells are incompletely… Expand
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Highly Cited
2005
Highly Cited
2005
Inflammation may underlie the metabolic disorders of insulin resistance and type 2 diabetes. IkappaB kinase beta (IKK-beta… Expand
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Highly Cited
2004
Highly Cited
2004
TANK-binding kinase-1 (TBK1) and the inducible IκB kinase (IKK-i) have been shown recently to activate interferon (IFN… Expand
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Highly Cited
2003
Highly Cited
2003
We previously reported a new Toll/IL-1R (TIR)-containing molecule, named TIR domain-containing adaptor inducing IFN-β (TRIF… Expand
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Highly Cited
2001
Highly Cited
2001
Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and may involve fat-induced activation of a serine… Expand
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Highly Cited
1997
Highly Cited
1997
Activation of the transcription factor nuclear factor kappa B (NF-kappaB) is controlled by sequential phosphorylation… Expand
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Highly Cited
1997
Highly Cited
1997
Abstract Activation of the transcription factor NF-κB by tumor necrosis factor (TNF) and interleukin-1 (IL-1) requires the NF-κB… Expand
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