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ITX-5061

Known as: ITX5061 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PhenylenediaminesSulfonamides

Papers overview

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2018
2018
Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1
Abstract Metastatic castration‐resistant prostate cancer (mCRPC) is a lethal form of treatment‐resistant prostate cancer and… Expand
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2018
2018
Sprouty 2 loss-induced IL 6 drives castration-resistant prostate cancer through scavenger receptor B 1
Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of treatment-resistant prostate cancer and poses… Expand
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2016
2016
Effect of scavenger receptor class B type I antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation.
Hepatitis C virus (HCV) entry inhibitors have been hypothesized to prevent infection of the liver after transplantation. ITX5061… Expand
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2014
2014
Safety and antiviral activity of the HCV entry inhibitor ITX5061 in treatment-naive HCV-infected adults: a randomized, double-blind, phase 1b study.
BACKGROUND Hepatitis C virus (HCV) entry involves scavenger receptor B1 (SRB1). In vitro, SRB1 inhibition by ITX5061 impedes HCV… Expand
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2014
2014
Effect of scavenger receptor B-I antagonist, ITX5061, on early hepatitis C virus kinetics in liver transplantation: results of a phase 1b clinical trial
Abstract Background Prevention of recurrent hepatitis C virus (HCV) infection after liver transplantation is a major unmet… Expand
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Review
2014
Review
2014
Antibodies to the High-Density Lipoprotein Receptor SR-B1 Potently Inhibit Hepatitis C Virus Replication In Vivo: New Avenues for Preventing Reinfection of the Liver Following Transplantation
See Article on Page 1508 Direct-acting antivirals (DAAs), together with pegylated interferon and ribavirin, have shown great… Expand
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2013
2013
Hepatitis C virus kinetics after liver transplantation to study the role of a small molecule inhibitor of viral entry
Abstract Background After liver transplantation in patients infected with hepatitis C virus (HCV), reinfection of the… Expand
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2011
2011
Hepatitis C virus entry receptor dynamics and studies of platelet actin dynamics using lifeact-gfp: a potential role for actin nodules in filopodia formation
Virus entry into target cells is mediated by the attachment of viral glycoproteins to cell surface receptors. Entry of the… Expand
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2009
2009
Increased HDL cholesterol and apoA-I in humans and mice treated with a novel SR-BI inhibitor.
OBJECTIVE Increasing HDL levels is a potential strategy for the treatment of atherosclerosis. METHODS AND RESULTS ITX5061, a… Expand
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