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ITX-5061

Known as: ITX5061 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PhenylenediaminesSulfonamides

Papers overview

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2018
2018
Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1
Metastatic castration‐resistant prostate cancer (mCRPC) is a lethal form of treatment‐resistant prostate cancer and poses… Expand
2018
2018
Sprouty 2 loss-induced IL 6 drives castration-resistant prostate cancer through scavenger receptor B 1
Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of treatment-resistant prostate cancer and poses… Expand
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2016
2016
Effect of scavenger receptor class B type I antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation
Hepatitis C virus (HCV) entry inhibitors have been hypothesized to prevent infection of the liver after transplantation. ITX5061… Expand
2014
2014
Safety and antiviral activity of the HCV entry inhibitor ITX5061 in treatment-naive HCV-infected adults: a randomized, double-blind, phase 1b study.
BACKGROUND Hepatitis C virus (HCV) entry involves scavenger receptor B1 (SRB1). In vitro, SRB1 inhibition by ITX5061 impedes HCV… Expand
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2014
2014
Effect of scavenger receptor B-I antagonist, ITX5061, on early hepatitis C virus kinetics in liver transplantation: results of a phase 1b clinical trial
Abstract Background Prevention of recurrent hepatitis C virus (HCV) infection after liver transplantation is a major unmet… Expand
Review
2014
Review
2014
Antibodies to the High-Density Lipoprotein Receptor SR-B1 Potently Inhibit Hepatitis C Virus Replication In Vivo: New Avenues for Preventing Reinfection of the Liver Following Transplantation
See Article on Page 1508 Direct-acting antivirals (DAAs), together with pegylated interferon and ribavirin, have shown great… Expand
2013
2013
Hepatitis C virus kinetics after liver transplantation to study the role of a small molecule inhibitor of viral entry
Abstract Background After liver transplantation in patients infected with hepatitis C virus (HCV), reinfection of the… Expand
2011
2011
Hepatitis C virus entry receptor dynamics and studies of platelet actin dynamics using lifeact-gfp: a potential role for actin nodules in filopodia formation
Virus entry into target cells is mediated by the attachment of viral glycoproteins to cell surface receptors. Entry of the… Expand
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Highly Cited
2009
Highly Cited
2009
Increased HDL Cholesterol and ApoA-I in Humans and Mice Treated With a Novel SR-BI Inhibitor
Objectives—Increasing HDL levels is a potential strategy for the treatment of atherosclerosis. Methods and Results—ITX5061, a… Expand
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