ITPA gene

Known as: dJ794I6.3, INOSINE TRIPHOSPHATASE, nucleoside-triphosphate diphosphatase 
 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND Pegylated interferon, ribavirin, and telaprevir triple therapy is a new strategy expected to eradicate the hepatitis C… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND & AIMS In a genome-wide association study of patients being treated for chronic hepatitis C, 2 functional variants in… (More)
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2010
2010
AIM Host genetic variants leading to inosine triphosphatase (ITPA) deficiency, a condition not thought to be clinically important… (More)
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2009
2009
Thiopurine drugs have to be withdrawn in 10–30% of cases due to side effects, and it has been presented that genetic factors may… (More)
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2007
2007
Inosine triphosphate pyrophosphatase (ITPase) catalyzes the conversion of inosine triphosphate (ITP) to the correspondent… (More)
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Highly Cited
2004
Highly Cited
2004
Adverse drug reactions to azathioprine (AZA), the pro-drug of 6-mercaptopurine (6-MP), occur in 15% to 28% of patients and the… (More)
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2004
2004
A 94C>A missense mutation in the ITPA gene which encodes inosine triphosphate pyrophosphatase has been associated with adverse… (More)
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2002
2002
AbstractIntracellular concentrations of the nucleotide inosine triphosphate (ITP) are regulated by ITP-ase (EC 3.6.1.19), which… (More)
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Highly Cited
2002
Highly Cited
2002
Inosine triphosphate pyrophosphohydrolase (ITPase) deficiency is a common inherited condition characterized by the abnormal… (More)
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2001
2001
ITP and dITP exist in all cells. dITP is potentially mutagenic, and the levels of these nucleotides are controlled by inosine… (More)
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