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ITMN-191

Known as: ITMN 191, ITMN191 
National Institutes of Health

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danoprevir

Papers overview

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2014
2014
Identification of weak points of hepatitis C virus NS3 protease inhibitors using surface plasmon resonance biosensor-based interaction kinetic analysis and genetic variants.
To aid the design of next generation hepatitis C virus (HCV) drugs, the kinetics of the interactions between NS3 protease… 
2012
2012
Understanding the structural and energetic basis of inhibitor and substrate bound to the full-length NS3/4A: insights from molecular dynamics simulation, binding free energy calculation and network…
Hepatitis C virus (HCV) bifunctional NS3/4A is an attractive anti-HCV drug target, as both the protease and helicase functions… 
2011
2011
Genotype-associated differences in susceptibility and resistance development of hepatitis C virus towards the protease inhibitors VX-950 (Telaprevir) and ITMN-191
2010
2010
753 IMPACT OF LOW DOSE RITONAVIR BOOSTING ON THE PHARMACOKINETICS OF RG7227 (ITMN-191), A HIGHLY POTENT AND SELECTIVE INHIBITOR OF THE HCV NS3/4A PROTEASE
2009
2009
936 COMBINATION OF THE NS3/4A PROTEASE INHIBITOR ITMN-191 WITH THE ALLOSTERIC NS5B POLYMERASE INHIBITOR ITMN-8020 ENHANCES REPLICON CLEARANCE AND REDUCES THE EMERGENCE OF DRUG RESISTANT VARIANTS
2009
2009
Gateways to clinical trials.
ABT-869, Acadesine, Acetylsalicylic acid/omeprazole, Adefovir, Adefovir dipivoxil, AEG-35156, Agatolimod sodium, Albiglutide… 
2008
2008
Practical consequences of hepatitis C virus quasispecies for target-specific antivirals.
Hepatitis C virus (HCV) exists as a swarm of similar but not identical isolates, called a “quasispecies” [1, 2]. Quasispecies… 
2007
2007
[576] ITMN-191 CONCENTRATIONS ACHIEVED IN THE LIVER OF ANIMALS PROMOTE HCV REPLICON CLEARANCE IN VITRO AND THIS EFFECT IS ENHANCED BY PEG-IFN ALPHA-2a
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