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ITGA2B gene

Known as: PLATELET GLYCOPROTEIN IIb, CD41B, PLATELET FIBRINOGEN RECEPTOR, ALPHA SUBUNIT 
This gene is involved in platelet aggregation.
National Institutes of Health

Related topics

Related topics

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Cell AdhesionITGA2B protein, humanLigand BindingPlatelet Membrane Glycoprotein IIb

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ITGA2B wt Allele

Papers overview

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2014
2014
Association of platelet ITGA2B and ITGB3 polymorphisms with ex vivo antiplatelet effect of ticagrelor in healthy Chinese male subjects
Ticagrelor (TIC) is the first reversible P2Y12 receptor antagonist that exhibits rapid antiplatelet effect by indirect inhibition… 
2013
2013
A V740L mutation in glycoprotein IIb defines a novel epitope (War) associated with fetomaternal alloimmune thrombocytopenia
Most recently described human platelet antigens (HPAs) have been detected in cases of fetomaternal alloimmune thrombocytopenia… 
Review
2012
Review
2012
Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment
Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to… 
Review
2009
Review
2009
Genetic testing in the diagnostic evaluation of inherited platelet disorders.
Inherited disorders of platelets give rise to rare bleeding syndromes through defects of platelet function and/or platelet… 
2008
2008
Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease
Summary We studied the effect of prophylactic aspirin (ASA) ingestion on platelet function in 463 patients with stroke, transient… 
2006
2006
Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure–function correlations of αIIbβ3 integrin (ITGA2B, ITGB3)
The molecular basis of Glanzmann thrombasthenia (GT) was studied in 40 families from southern India. Of 23 identified mutations… 
2000
2000
Combination of a Direct Thrombin Inhibitor and a Platelet Glycoprotein IIb/IIIa Blocking Peptide Facilitates and Maintains Reperfusion of Platelet-Rich Thrombus with Alteplase
We sought to determine the efficacy of the combination of argatroban, a direct thrombin inhibitor, and G4120, a platelet… 
Review
1995
Review
1995
Novel antithrombotic therapeutics targeted against platelet glycoprotein IIb/IIIa.
Platelet aggregation is one of the best understood examples of adhesive cell-cell interactions. The platelet glycoprotein IIb… 
1991
1991
Study of the endoproteolytic cleavage of platelet glycoprotein IIb using oligonucleotide-mediated mutagenesis.
Highly Cited
1986
Highly Cited
1986
Identification of platelet glycoprotein IIb/IIIa as the major binding site for released platelet-von Willebrand factor.
We studied the effects(s) of two monoclonal antibodies, 6D1 and 10E5 (directed against platelet glycoprotein Ib [GPIb] and the… 
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