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ITGA2B gene
Known as:
PLATELET GLYCOPROTEIN IIb
, CD41B
, PLATELET FIBRINOGEN RECEPTOR, ALPHA SUBUNIT
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This gene is involved in platelet aggregation.
National Institutes of Health
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Related topics
Related topics
9 relations
Cell Adhesion
ITGA2B protein, human
Ligand Binding
Platelet Membrane Glycoprotein IIb
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Narrower (1)
ITGA2B wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia
L. Bury
,
E. Falcinelli
,
D. Chiasserini
,
T. Springer
,
J. Italiano
,
P. Gresele
Haematologica
2016
Corpus ID: 207686756
Several patients have been reported to have variant dominant forms of Glanzmann thrombasthenia, associated with…
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Review
2011
Review
2011
Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models.
A. Nurden
,
M. Fiore
,
P. Nurden
,
X. Pillois
Blood
2011
Corpus ID: 9991487
Characterized by mucocutaneous bleeding arising from a lack of platelet aggregation to physiologic stimuli, Glanzmann…
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Highly Cited
2011
Highly Cited
2011
An environmental Wnt16/Notch pathway specifies haematopoietic stem cells
W. Clements
,
Albert D Kim
,
K. Ong
,
John C Moore
,
N. Lawson
,
D. Traver
Nature
2011
Corpus ID: 4403459
Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously replenish all blood and immune cells…
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Highly Cited
2011
Highly Cited
2011
Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.
S. Kunishima
,
H. Kashiwagi
,
+9 authors
H. Saito
Blood
2011
Corpus ID: 206897808
Congenital macrothrombocytopenia is a genetically heterogeneous group of rare disorders. αIIbβ3 has not been implicated in these…
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Review
2000
Review
2000
Immediate coronary artery bypass surgery after platelet inhibition with eptifibatide: results from PURSUIT. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrelin…
C. Dyke
,
D. Bhatia
,
+4 authors
R. Harrington
Annals of Thoracic Surgery
2000
Corpus ID: 6671001
Highly Cited
2000
Highly Cited
2000
Management of Patients With Acute Coronary Syndromes in the United States by Platelet Glycoprotein IIb/IIIa Inhibition: Insights From the Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor…
A. Lincoff
,
R. Harrington
,
+11 authors
E. Topol
Circulation
2000
Corpus ID: 1103176
BackgroundA multinational, randomized, placebo-controlled trial (Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor…
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Highly Cited
1999
Highly Cited
1999
Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina. Receptor suppression using integrilin therapy (PURSUIT) trial. The…
K. Mahaffey
,
R. Harrington
,
+12 authors
R. Califf
Circulation
1999
Corpus ID: 34903456
BACKGROUND The incidence of stroke in patients with acute coronary syndromes has not been clearly defined because few trials in…
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Highly Cited
1997
Highly Cited
1997
Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men.
T. Müller
,
Hans Weisenberger
,
Rolf Brickl
,
Hans Narjes
,
Frank Himmelsbach
,
Jürgen Krause
Circulation
1997
Corpus ID: 25770944
BACKGROUND Clinical trials have demonstrated that platelet glycoprotein (GP) IIb/IIIa antagonists effectively prevent acute…
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1988
1988
A Monoclonal Antibody to the Human Platelet Glycoprotein II b/III a Complex Induces Platelet Activation
P. Modderman
,
H. Huisman
,
J. Mourik
,
A. Borne
Thrombosis and Haemostasis
1988
Corpus ID: 36807739
Summary The platelet glycoprotein (GP) IIb/IIIa complex functions as the receptor for fibrinogen on activated platelets. The…
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Highly Cited
1986
Highly Cited
1986
Identification of platelet glycoprotein IIb/IIIa as the major binding site for released platelet-von Willebrand factor.
R. Parker
,
H. Gralnick
Blood
1986
Corpus ID: 15498486
We studied the effects(s) of two monoclonal antibodies, 6D1 and 10E5 (directed against platelet glycoprotein Ib [GPIb] and the…
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