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ISG15 activating enzyme activity

Known as: UBE1L 
Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The androgen receptor (AR) plays a crucial role in the modulation of prostate cell proliferation and is involved in the… Expand
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Highly Cited
2008
Highly Cited
2008
ABSTRACT ISG15 functions as a critical antiviral molecule against influenza virus, with infection inducing both the conjugation… Expand
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2008
2008
Acute promyelocytic leukemia (APL) is characterized by expression of promyelocytic leukemia (PML)/retinoic acid (RA) receptor… Expand
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Highly Cited
2008
Highly Cited
2008
Hepatitis B virus (HBV) causes both acute and chronic infection of the human liver and is associated with the development of… Expand
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Highly Cited
2008
Highly Cited
2008
UBE1L is the E1-like ubiquitin-activating enzyme for the IFN-stimulated gene, 15-kDa protein (ISG15). The UBE1L-ISG15 pathway was… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT The expression of ubiquitin-like modifier ISG15 and its conjugation to target proteins are highly induced by interferon… Expand
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Highly Cited
2006
Highly Cited
2006
Type I IFNs induce the expression of IFN-stimulated gene 15 (ISG15) and its conjugation to cellular targets. ISGylation is a… Expand
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Highly Cited
2005
Highly Cited
2005
ISG15 is a ubiquitin-like protein that is upregulated on treatment with interferon. ISG15 is considered to be covalently… Expand
Highly Cited
2004
Highly Cited
2004
Acute promyelocytic leukemia (APL) cases expressing the t(15,17) product, promyelocytic leukemia (PML)/retinoic acid receptor… Expand
Review
2003
Review
2003
The retinoids are natural and synthetic derivatives of vitamin A. These cancer therapeutic and chemopreventive agents exert anti… Expand