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ISG15 activating enzyme activity

Known as: UBE1L 
Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond… Expand
National Institutes of Health

Related topics

Related topics

1 relation
UBA7 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Expression, regulation and function of the ISGylation system in prostate cancer
The androgen receptor (AR) plays a crucial role in the modulation of prostate cell proliferation and is involved in the… Expand
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Highly Cited
2008
Highly Cited
2008
Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection
ABSTRACT ISG15 functions as a critical antiviral molecule against influenza virus, with infection inducing both the conjugation… Expand
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2008
2008
UBE1L represses PML/RARα by targeting the PML domain for ISG15ylation
Acute promyelocytic leukemia (APL) is characterized by expression of promyelocytic leukemia (PML)/retinoic acid (RA) receptor… Expand
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Highly Cited
2008
Highly Cited
2008
The Level of Hepatitis B Virus Replication Is Not Affected by Protein ISG15 Modification but Is Reduced by Inhibition of UBP43 (USP18) Expression1
Hepatitis B virus (HBV) causes both acute and chronic infection of the human liver and is associated with the development of… Expand
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Highly Cited
2008
Highly Cited
2008
UBE1L causes lung cancer growth suppression by targeting cyclin D1
UBE1L is the E1-like ubiquitin-activating enzyme for the IFN-stimulated gene, 15-kDa protein (ISG15). The UBE1L-ISG15 pathway was… Expand
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Highly Cited
2006
Highly Cited
2006
Ube1L and Protein ISGylation Are Not Essential for Alpha/Beta Interferon Signaling
ABSTRACT The expression of ubiquitin-like modifier ISG15 and its conjugation to target proteins are highly induced by interferon… Expand
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Highly Cited
2006
Highly Cited
2006
HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.
Type I IFNs induce the expression of IFN-stimulated gene 15 (ISG15) and its conjugation to cellular targets. ISGylation is a… Expand
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Highly Cited
2005
Highly Cited
2005
Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.
ISG15 is a ubiquitin-like protein that is upregulated on treatment with interferon. ISG15 is considered to be covalently… Expand
Highly Cited
2004
Highly Cited
2004
Involvement of UBE1L in ISG15 Conjugation during Retinoid-induced Differentiation of Acute Promyelocytic Leukemia*
Acute promyelocytic leukemia (APL) cases expressing the t(15,17) product, promyelocytic leukemia (PML)/retinoic acid receptor… Expand
Review
2003
Review
2003
Retinoid Targets in Cancer Therapy and Chemoprevention
The retinoids are natural and synthetic derivatives of vitamin A. These cancer therapeutic and chemopreventive agents exert anti… Expand
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