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ISG15 activating enzyme activity

Known as: UBE1L 
Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond… Expand
National Institutes of Health

Related topics

Related topics

1 relation
UBA7 gene

Papers overview

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Highly Cited
2009
Highly Cited
2009
Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.
ISG15 functions as a critical antiviral molecule against influenza virus, with infection inducing both the conjugation of ISG15… Expand
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2008
2008
The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression.
Hepatitis B virus (HBV) causes both acute and chronic infection of the human liver and is associated with the development of… Expand
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2008
2008
UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation.
Acute promyelocytic leukemia (APL) is characterized by expression of promyelocytic leukemia (PML)/retinoic acid (RA) receptor… Expand
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2008
2008
HyperISGylation of Old World Monkey ISG15 in Human Cells
BACKGROUND ISG15 is an Ubiquitin-like protein, highly induced by Type I Interferons. Upon the cooperative activity of specific… Expand
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Highly Cited
2006
Highly Cited
2006
Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.
The expression of ubiquitin-like modifier ISG15 and its conjugation to target proteins are highly induced by interferon (IFN… Expand
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Highly Cited
2006
Highly Cited
2006
HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.
Type I IFNs induce the expression of IFN-stimulated gene 15 (ISG15) and its conjugation to cellular targets. ISGylation is a… Expand
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2005
2005
Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.
ISG15 is a ubiquitin-like protein that is upregulated on treatment with interferon. ISG15 is considered to be covalently… Expand
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2005
2005
Isolation and Sequence of an Interferon-τ-Inducible, Pregnancy- and Bovine Interferon-Stimulated Gene Product 15 (ISG15)-Specific, Bovine Ubiquitin-Activating E1-Like (UBE1L) Enzyme1
Abstract Bovine (bov) interferon-stimulated gene product 15 (ISG15) is produced in the endometrium in response to conceptus… Expand
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2004
2004
Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.
Acute promyelocytic leukemia (APL) cases expressing the t(15,17) product, promyelocytic leukemia (PML)/retinoic acid receptor… Expand
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Review
2003
Review
2003
Retinoid targets in cancer therapy and chemoprevention.
The retinoids are natural and synthetic derivatives of vitamin A. These cancer therapeutic and chemopreventive agents exert anti… Expand
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