FAQ

ISG15 activating enzyme activity

Known as: UBE1L 
Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2016
02419942016

Related topics

Related topics

1 relation
UBA7 gene

Related mentions per year

Related mentions per year

1989-2018
19801990200020102020
ISG15 activating enzyme activity
UBA7 gene

Papers overview

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2008
2008
Different roles for two ubiquitin-like domains of ISG15 in protein modification.
ISG15 (interferon-stimulated gene 15) is a novel ubiquitin-like (UbL) modifier with two UbL domains in its architecture. We… (More)
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2008
2008
The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression.
Hepatitis B virus (HBV) causes both acute and chronic infection of the human liver and is associated with the development of… (More)
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Highly Cited
2006
Highly Cited
2006
The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase.
The expression of the ubiquitin-like protein ISG15 and protein modification by ISG15 (ISGylation) are strongly activated by… (More)
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2006
2006
Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.
The expression of ubiquitin-like modifier ISG15 and its conjugation to target proteins are highly induced by interferon (IFN… (More)
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2006
2006
Identification and Herc5-mediated ISGylation of novel target proteins.
ISG15, a protein containing two ubiquitin-like domains, is an interferon-stimulated gene product that functions in antiviral… (More)
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Highly Cited
2004
Highly Cited
2004
Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation.
Protein ISGylation is unique among ubiquitin-like conjugation systems in that the expression and conjugation processes are… (More)
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2004
2004
Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.
Acute promyelocytic leukemia (APL) cases expressing the t(15,17) product, promyelocytic leukemia (PML)/retinoic acid receptor… (More)
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2002
2002
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
All-trans-retinoic acid (RA) treatment induces remissions in acute promyelocytic leukemia (APL) cases expressing the t(15;17… (More)
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Highly Cited
2001
Highly Cited
2001
Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.
Of the several hundred proteins induced by interferon (IFN) alpha/beta, the ubiquitin-like ISG15 protein is one of the most… (More)
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1994
1994
A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes.
All types of lung carcinoma are characterized by a high frequency of loss of sequences from the short arm of chromosome 3, the… (More)
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