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Early life exposure to endocrine-disrupting chemicals (EDCs) is an emerging risk factor for the development of obesity and… Expand e14095Background: IRX4204 is a Retinoid X Receptor (RXR) specific agonist (rexinoid). IRX4204 has high potency as a RXR agonist… Expand Obesity is a global pandemic. Nearly 40% of adults and 20% of all children in the United States are classified as obese. There… Expand Retinoid x receptors (RXRs) are master regulators that control cell growth, differentiation, and survival and form heterodimers… Expand Parkinson's disease (PD) is one of the most common movement disorders, and currently there is no effective treatment that can… Expand Objective: To evaluate the safety, tolerability, and effects on dopamine transporter binding (DAT), UPDRS Total and Motor Score… Expand Objective: To facilitate translation of the selective RXR nuclear receptor agonist IRX4204 into clinical trials in MS and other… Expand 169 Background: IRX4204 is a potent, selective, oral small compound agonist of retinoid X receptor (RXR) nuclear receptor… Expand Background: Activation of retinoid X receptors (RXR) as homodimers, or as heterodimers with other nuclear receptors, results in… Expand Background: IRX4204 is a potent and highly selective small compound agonist of the RXR nuclear receptors. IRX4204 transactivates… Expand