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IRX4204

National Institutes of Health

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Cyclopropanes

Papers overview

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2017
2017
IRX4204 in combination with erlotinib to target distinct pathways in lung cancer cells.
e14095Background: IRX4204 is a Retinoid X Receptor (RXR) specific agonist (rexinoid). IRX4204 has high potency as a RXR agonist… 
2016
2016
The Retinoid X Receptor (RXR) Selective Agonist IRX4204 Promotes Differentiation of Human Treg Cells and Inhibits Differentiation of Human TH17 Cells (P5.272)
Objective: To facilitate translation of the selective RXR nuclear receptor agonist IRX4204 into clinical trials in MS and other… 
2014
2014
An open-label phase II clinical trial of the RXR agonist IRX4204 in taxane-resistant, castration-resistant metastatic prostate cancer (CRPC).
169 Background: IRX4204 is a potent, selective, oral small compound agonist of retinoid X receptor (RXR) nuclear receptor… 
2014
2014
IRX4204: A Clinical Stage, Potent, and Highly Selective RXR Agonist Compound Is Brain Penetrant, and Promotes Differentiation of Oligodendrocyte Precursor Cells (OPCs) In Vitro (I7-2.001)
Background: IRX4204 is a potent and highly selective small compound agonist of the RXR nuclear receptors. IRX4204 transactivates… 
2014
2014
IRX4204: A Highly Selective RXR Agonist Modulates Adaptive Treg Differentiation Independent of RAR, and Effectively Inhibits Central Nervous System Inflammation (S14.005)
Background: Activation of retinoid X receptors (RXR) as homodimers, or as heterodimers with other nuclear receptors, results in… 
2013
2013
IRX4204 As a novel disease-modifying compound for treatment of Parkinson'/INS;s disease
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