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IRF1 protein, human

Known as: Interferon Regulatory Factor 1, IRF-1, interferon regulatory factor 1, human 
Interferon regulatory factor 1 (325 aa, ~37 kDa) is encoded by the human IRF1 gene. This protein plays a role in the regulation of interferon gene… 
National Institutes of Health

Related topics

Related topics

11 relations
ApoptosisDNA-Binding ProteinsGenes, RegulatorIRF1 gene

Broader (1)

Interferon Regulatory Factor 1

Papers overview

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Highly Cited
2011
Highly Cited
2011
A diverse array of gene products are effectors of the type I interferon antiviral response
The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence… 
Highly Cited
2002
Highly Cited
2002
Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway
The mechanism by which genotoxic stress induces IRF-1 and the signalling components upstream of this anti-oncogenic transcription… 
Highly Cited
2001
Highly Cited
2001
A Specific Interferon (IFN)-stimulated Response Element of the Distal HLA-G Promoter Binds IFN-regulatory Factor 1 and Mediates Enhancement of This Nonclassical Class I Gene by IFN-β*
Type I interferons display a broad range of immunomodulatory functions. Interferon β increases gene expression at the… 
Highly Cited
2000
Highly Cited
2000
The IFN Regulatory Factor Family Participates in Regulation of Fas Ligand Gene Expression in T Cells
TCR engagement leads to the transcriptional activation of cytokine genes and activation-induced cell death. Activated T cells… 
Highly Cited
2000
Highly Cited
2000
Deficiency in the Transcription Factor Interferon Regulatory Factor (Irf)-2 Leads to Severely Compromised Development of Natural Killer and T Helper Type 1 Cells
Interferon (IFN) regulatory factor (IRF)-2 was originally described as an antagonist of IRF-1–mediated transcriptional regulation… 
Highly Cited
1998
Highly Cited
1998
Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
The family of interferon regulatory factor (IRF) transcription factors is important in the regulation of interferons in response… 
Highly Cited
1998
Highly Cited
1998
Two families of GTPases dominate the complex cellular response to IFN-gamma.
IFN-gamma induces a number of cellular programs functional in innate and adaptive resistance to infectious pathogens. It has… 
Highly Cited
1995
Highly Cited
1995
Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
A family of interferon (IFN) regulatory factors (IRFs) have been shown to play a role in transcription of IFN genes as well as… 
Highly Cited
1995
Highly Cited
1995
Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1
Transcription of the vascular cell adhesion molecule 1 (VCAM-1) gene in endothelial cells is induced by lipopolysaccharide and… 
Highly Cited
1990
Highly Cited
1990
Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated
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