IRAK1 protein, human

Known as: interleukin-1 receptor-associated kinase 1, human, Pelle Homolog, IRAK-1 
Interleukin-1 receptor-associated kinase 1 (712 aa, ~77 kDa) is encoded by the human IRAK1 gene. This protein plays a role in protein phosphorylation… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
020406019982018

Papers overview

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Highly Cited
2011
Highly Cited
2011
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains the least curable form of this… (More)
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Highly Cited
2009
Highly Cited
2009
Upon recognition of viral components by pattern recognition receptors, including TLRs and retinoic acid-inducible gene I (RIG-I… (More)
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Highly Cited
2008
Highly Cited
2008
Although papillary thyroid carcinoma (PTC) displays strong heritability, no predisposing germ-line mutations have been found. We… (More)
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Highly Cited
2008
Highly Cited
2008
Members of the IRAK family of kinases mediate Toll-like receptor (TLR) signaling. Here we show that IRAK2 was essential for… (More)
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Highly Cited
2004
Highly Cited
2004
Although oxidative stress has been thought to play a general role in the activation of NF-kappaB, the involvement of reactive… (More)
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Highly Cited
2004
Highly Cited
2004
Cancers originating from epithelial cells are the most common malignancies. No common expression profile of solid tumors compared… (More)
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Highly Cited
2003
Highly Cited
2003
Toll-like receptor-4 (TLR4) can be activated by nonbacterial agonists, including saturated fatty acids. However, downstream… (More)
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Highly Cited
2003
Highly Cited
2003
Toll-like receptors (TLRs) and members of the proinflammatory interleukin 1 receptor (IL-1R) family are dependent on the presence… (More)
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Highly Cited
2002
Highly Cited
2002
Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, and members of the pro-inflammatory… (More)
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Highly Cited
2002
Highly Cited
2002
Toll/IL-1 receptor family members are central components of host defense mechanisms in a variety of species. One well conserved… (More)
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