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IRAK1 protein, human

Known as: interleukin-1 receptor-associated kinase 1, human, Pelle Homolog, IRAK-1 
Interleukin-1 receptor-associated kinase 1 (712 aa, ~77 kDa) is encoded by the human IRAK1 gene. This protein plays a role in protein phosphorylation… 
National Institutes of Health

Related topics

Related topics

17 relations
ApoptosisBeta-Catenin Accumulation PathwayEnzyme GeneIRAK1 gene

Broader (2)

Interleukin-1 Receptor-Associated Kinasesinterleukin-1 receptor-associated kinase 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Pacritinib (PAC) vs best available therapy (BAT) in myelofibrosis (MF): 60 week follow-up of the phase III PERSIST-1 trial.
7065Background: Effective treatment (Tx) options for patients (pts) with MF that do not induce myelosuppression are limited. PAC… 
2016
2016
G 2013 modulates TLR 4 signaling pathway in IRAK-1 and TARF-6 dependent and miR-146 a independent manner
Inflammation is inseparable part of different diseases especially cancer and autoimmunity. During inflammation process toll like… 
2015
2015
MECP2 duplication syndrome in a Chinese family
BackgroundMethyl-CpG-binding protein 2 (MeCP2) is a key transcriptional regulator of gene expression in the maintenance and… 
2014
2014
MicroRNA-146a expression and its intervention in NF-кB signaling pathway in diabetic rat aorta.
OBJECTIVE The present study was designed to evaluate whether microRNA-146a, as an NF-кB regulating factor and its adapter… 
2013
2013
Potent suppression of arginase 1 expression in murine macrophages by low dose endotoxin.
Macrophages can respond to diverse signals and adopt multiple phenotypes. Although interleukin-4 (IL-4) is shown to potently… 
2012
2012
Mycoepoxydiene Inhibits Lipopolysaccharide-Induced Inflammatory Responses through the of TRAF6 Polyubiquitination
Mycoepoxydiene (MED) is a polyketide isolated from a marine fungus associated with mangrove forests. MED has been shown to be… 
2009
2009
MAPPIT (mammalian protein-protein interaction trap) analysis of early steps in toll-like receptor signalling.
The mammalian protein-protein interaction trap (MAPPIT) is a two-hybrid technique founded on type I cytokine signal transduction… 
2008
2008
Mechanistic analysis of macrophage response to IRAK-1 gene knockdown by a smart polymer-antisense oligonucleotide therapeutic
An excessive inflammatory response is a clinical problem following major infections and severe injury that may lead to Sepsis… 
2003
2003
Association of a Haplotype (196Phe/532Ser) in the Interleukin‐1‐Receptor‐Associated Kinase (IRAK1) Gene With Low Radial Bone Mineral Density in Two Independent Populations
Osteoporosis, a multifactorial common disease, is believed to result from the interplay of multiple environmental and genetic… 
2000
2000
Antisense IRAK-1 oligonucleotide blocks activation of NF-kappa B and AP-1 induced by IL-18.
Interleukin-18 (IL-18) is a novel proinflammatory cytokine. Most of the immune and inflammatory genes induced by IL-18 are… 
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