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Background: Cationic antimicrobial peptides offer an alternative to conventional antibiotics, as they physically disrupt… Expand The PAR2 receptors are involved in chronic arthritis by mechanisms that are as yet unclear. Here, we examined PAR2 activation in… Expand The objective of this study was to evaluate the tolerability, to establish a dosing regimen, and to evaluate the efficacy of… Expand Leu-enkephalin is an endogenous pain modulating opioid pentapeptide. Its development as a potential pharmaceutic has been… Expand Protease‐activated receptor‐2 (PAR‐2) is a G‐protein‐coupled receptor activated through proteolytic cleavage. It is localized on… Expand Background and purpose: Activation of the proteinase‐activated receptor‐2 (PAR‐2) induces scratching behaviour in mice. Here, we… Expand Itch, an unpleasant sensation associated with the desire to scratch, is symptomatic of dermatologic and systemic disorders that… Expand We previously demonstrated that stimulation of proteinase-activated receptor-2 (PAR-2) by SLIGRL-NH(2) elicits afferent… Expand BACKGROUND AND AIMS
On activation, protease-activated receptor (PAR)-2 modulates multiple gastric functions and exerts mucosal… Expand Because thrombin-induced inflammation is partially mast cell-dependent and involves proteinase-activated receptors (PARs), we… Expand