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IL6R protein, human

Known as: interleukin 6 receptor protein, human, gp80, CD126 Antigen 
Interleukin-6 receptor subunit alpha (468 aa, ~52 kDa) is encoded by the human IL6R gene. This protein plays a role in regulation of the immune… 
National Institutes of Health

Related topics

Related topics

22 relations
Biologic DevelopmentCell ProliferationCytokine Receptor GeneCytokine Signaling Process
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Broader (2)

Interleukin 6 ReceptorInterleukin-6 Receptor alpha Subunit

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
The pleiotropic activities of Interleukin (IL-)6 are controlled by membrane-bound and soluble forms of the IL-6 receptor (IL-6R… 
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Highly Cited
2003
Highly Cited
2003
Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma
Proteasome inhibitor PS-341 is one of the most promising novel agents against multiple myeloma (MM). We have previously shown… 
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Highly Cited
2003
Highly Cited
2003
The Exocyst Affects Protein Synthesis by Acting on the Translocation Machinery of the Endoplasmic Reticulum*
We previously showed that the exocyst complex specifically affected the synthesis and delivery of secretory and basolateral… 
Highly Cited
2002
Highly Cited
2002
Reduced oviposition of Boophilus microplus feeding on sheep vaccinated with vitellin.
The most abundant protein present in Boophilus microplus eggs, vitellin, was isolated and purified as a non-covalent complex of… 
Review
1997
Review
1997
The structural and functional basis of cytokine receptor activation: lessons from the common beta subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5…
CYTOKINE RECEPTORS are cell-surface glycoproteins that bind specifically to cytokines and transduce their signals. These… 
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Highly Cited
1997
Highly Cited
1997
Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow.
Both estrogen and androgen exert their antiosteoporotic effects, at least in part, by inhibiting IL-6 production, thereby… 
Highly Cited
1996
Highly Cited
1996
Interleukin‐6 Induces Expression of Peripherin and Cooperates with Trk Receptor Signaling to Promote Neuronal Differentiation in PC12 Cells
Abstract: In contrast to the intensively studied nerve growth factor (NGF)‐related family of cytokines, relatively little is… 
Highly Cited
1993
Highly Cited
1993
The soluble interleukin‐6 receptor is generated by shedding
The ligand‐binding subunit (gp80) of the human interleukin‐6 receptor (IL‐6R) was transiently expressed in COS‐7 cells. The… 
Highly Cited
1990
Highly Cited
1990
Differentiation of an epithelium: factors affecting the polarized distribution of Na+,K(+)-ATPase in mouse trophectoderm.
Na+,K(+)-ATPase is a marker of the basolateral plasma membrane domain of polarized epithelial cells, including the mural… 
Highly Cited
1983
Highly Cited
1983
Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue
An antiserum against material shed into serum-free medium by MCF-7 human mammary carcinoma cells (anti-SFM II) disrupts cell-cell… 
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