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IL6 Signaling Pathway

Known as: IL 6 signaling pathway 
Interleukin-6 (IL-6) is a cytokine that provokes a broad range of cellular and physiological responses. In addition to playing a role in inflammation… 
National Institutes of Health

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CSNK2A1 wt AlleleELK1 wt AlleleFOS wt AlleleHRAS wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Interleukin 6 trans-signalling : cardiovascular risk marker or therapeutical target?
Background: Interleukin (IL) 6 signals in two pathways. In classical signalling, essential in antimicrobial defence and tissue… 
2017
2017
Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B Cell Malignancies: Results from a Phase I Dose Escalation Study
Abstract Preclinical studies suggest that the spleen tyrosine kinase (SYK) and Janus kinase (JAK) family members can contribute… 
2016
2016
CD 126 and Targeted Therapy with Tocilizumab in Chronic Lymphocytic Leukemia
Purpose: IL6 promotes tumor growth and signal transduction via both its membrane-bound (CD126) and soluble receptors (sCD126). We… 
2013
2013
IL6 trans-signaling promotes functional recovery of hypofunctional phagocytes through STAT3 activation during peritonitis
The role of high interleukin 6 (IL6) levels has not been clearly explained in severe sepsis. We show that the augmentation of the… 
2010
2010
Abstract A21: Global DNA methylation analysis of bronchial epithelia of former smokers with COPD, with and without lung cancer
Introduction: Emerging evidence suggests that aberrant epigenetic regulation is involved in the development and progression of… 
1999
1999
Involvement of STAT3/APRF in IL 6 signal transduction pathway
Involvement of STAT3/APRF in IL6 signal transduction pathway$$$$ LI Yan, LAI Chunning, LIN Hong, et al. Institute of Basic… 
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