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IGF1R wt Allele

Known as: IGFIR, JTK13, Insulin Like Growth Factor 1 Receptor wt Allele 
Human IGF1R wild-type allele is located in the vicinity of 15q26.3 and is approximately 309 kb in length. This allele, which encodes insulin-like… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Although many cancers initially respond to cisplatin (CDDP)-based chemotherapy, resistance frequently develops. Insulin-like… Expand
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Highly Cited
2010
Highly Cited
2010
Antiangiogenic treatment activity has been reported in solitary fibrous tumor (SFT), a rare and little chemosensitive sarcoma. We… Expand
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Highly Cited
2009
Highly Cited
2009
Despite the frequent presence of an insulin-like growth factor I receptor (IGFIR)-mediated autocrine loop in osteosarcoma (OS… Expand
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Highly Cited
2008
Highly Cited
2008
Although some cancers are initially sensitive to EGFR tyrosine kinase inhibitors (TKIs), resistance invariably develops. We… Expand
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Highly Cited
2008
Highly Cited
2008
The insulin-like growth factor I receptor (IGFIR) and HER2 display important signaling interactions in breast cancer. We examined… Expand
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Highly Cited
2005
Highly Cited
2005
IntroductionActivation of the type I insulin-like growth factor receptor (IGFIR) promotes proliferation and inhibits apoptosis in… Expand
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Highly Cited
1997
Highly Cited
1997
The insulin receptor (IR) and type 1 insulin-like growth factor (IGF-I) receptor (IGFR) are both widely expressed in mammalian… Expand
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Highly Cited
1997
Highly Cited
1997
The 14-3-3 proteins have been implicated as potential regulators of diverse signaling pathways. Here, using two-hybrid assays and… Expand
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Highly Cited
1997
Highly Cited
1997
We have used a yeast two-hybrid system to identify proteins which bind to the cytosolic portion of the type 1 insulin-like growth… Expand
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Highly Cited
1995
Highly Cited
1995
Insulin receptor substrate-1 (IRS-1) and SHC become rapidly phosphorylated upon tyrosines after insulin-like growth factor I… Expand
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