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IGF-methotrexate Conjugate

Known as: 765IGF-MTX 
A conjugate containing the antimetabolite and antifolate agent methotrexate conjugated to insulin-like growth factor (IGF), with potential… 
National Institutes of Health

Papers overview

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2019
2019
Phase I Study of IGF-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R
Supplemental Digital Content is available in the text. Objectives: Insulin-like growth factor-methotrexate (IGF-MTX) is a… 
2014
2014
Phase I study of IGF-methotrexate conjugate in the treatment of refractory malignancies expressing IGF-1R.
TPS2635 Background: The insulin-like growth factor 1 receptor (IGF-1R) is overexpressed in multiple malignancies, including… 
2009
2009
Novel insulin-like growth factor-methotrexate covalent conjugate inhibits tumor growth in vivo at lower dosage than methotrexate alone.
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