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A conjugate containing the antimetabolite and antifolate agent methotrexate conjugated to insulin-like growth factor (IGF), with potential…
National Institutes of Health
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Phase I Study of IGF-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R
American journal of clinical oncology
Corpus ID: 204814741
Supplemental Digital Content is available in the text. Objectives: Insulin-like growth factor-methotrexate (IGF-MTX) is a…
Phase I study of IGF-methotrexate conjugate in the treatment of refractory malignancies expressing IGF-1R.
Rozina A. Chowdhery
Corpus ID: 80101002
TPS2635 Background: The insulin-like growth factor 1 receptor (IGF-1R) is overexpressed in multiple malignancies, including…
Novel insulin-like growth factor-methotrexate covalent conjugate inhibits tumor growth in vivo at lower dosage than methotrexate alone.
Translational research : the journal of…
Corpus ID: 24254068
The insulin-like growth factor receptor is overexpressed on many types of cancer cells and has been implicated in metastasis and…
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