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IDO Inhibitor NLG919

Known as: GDC-0919, NLG-919, NLG919 
An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
IDO blockade-based immunotherapy has been impeded by the activation of antitumor immune response and low delivery efficiency of… Expand
2019
2019
Purpose: IDO1 induces immune suppression in T cells through l-tryptophan (Trp) depletion and kynurenine (Kyn) accumulation in the… Expand
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2019
2019
Photodynamic therapy (PDT) has attracted growing attention in the field of cancer therapy due to its non-invasive intervention… Expand
Highly Cited
2018
Highly Cited
2018
Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response… Expand
Highly Cited
2018
Highly Cited
2018
Checkpoint blockade immunotherapy is promising for clinical treatment of various malignant tumors. However, checkpoint blockade… Expand
2018
2018
Purpose: Immune checkpoint inhibitors designed to revert tumor-induced immunosuppression have emerged as potent anticancer… Expand
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Highly Cited
2016
Highly Cited
2016
Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors, is a therapeutic target for the cancer immunotherapy. A… Expand
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Review
2015
Review
2015
Indoleamine 2, 3-dioxygenase 1 (IDO1), IDO2, and tryptophan 2, 3-dioxygenase (TDO) comprise a family of enzymes that catalyze the… Expand
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2015
2015
Background The immunoregulatory properties of mesenchymal stem cells (MSCs) have been well characterized in vitro. However, the… Expand
Highly Cited
2013
Highly Cited
2013
The IDO pathway mediates immunosuppressive effects through the metabolization of tryptophan (Trp) to kynurenine (Kyn), triggering… Expand