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IDO blockade-based immunotherapy has been impeded by the activation of antitumor immune response and low delivery efficiency of… Expand Purpose: IDO1 induces immune suppression in T cells through l-tryptophan (Trp) depletion and kynurenine (Kyn) accumulation in the… Expand Photodynamic therapy (PDT) has attracted growing attention in the field of cancer therapy due to its non-invasive intervention… Expand Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response… Expand Checkpoint blockade immunotherapy is promising for clinical treatment of various malignant tumors. However, checkpoint blockade… Expand Purpose: Immune checkpoint inhibitors designed to revert tumor-induced immunosuppression have emerged as potent anticancer… Expand Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors, is a therapeutic target for the cancer immunotherapy. A… Expand Indoleamine 2, 3-dioxygenase 1 (IDO1), IDO2, and tryptophan 2, 3-dioxygenase (TDO) comprise a family of enzymes that catalyze the… Expand Background The immunoregulatory properties of mesenchymal stem cells (MSCs) have been well characterized in vitro. However, the… Expand The IDO pathway mediates immunosuppressive effects through the metabolization of tryptophan (Trp) to kynurenine (Kyn), triggering… Expand