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IDO Inhibitor NLG919

Known as: GDC-0919, NLG-919, NLG919 
An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon… Expand
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response… Expand
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2017
2017
To achieve synergistic therapeutic efficacy and prevent cancer relapse, chemotherapy and immunotherapy have been combined as a… Expand
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Review
2017
Review
2017
Over the last decade, tryptophan catabolism has been firmly established as a powerful mechanism of innate and adaptive immune… Expand
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2017
2017
105Background: GDC-0919, a small molecule inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), reduces tryptophan catabolism and… Expand
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2016
2016
Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors, is a therapeutic target for the cancer immunotherapy. A… Expand
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Highly Cited
2016
Highly Cited
2016
Immunochemotherapy combines a chemotherapeutic agent with an immune-modulating agent and represents an attractive approach to… Expand
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2015
2015
BACKGROUND The immunoregulatory properties of mesenchymal stem cells (MSCs) have been well characterized in vitro. However, the… Expand
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2014
2014
Background The enzyme Indoleamine 2,3-dioxygenase (IDO1) catalyzes the cleavage of L-tryptophan, resulting in the production of… Expand
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2013
2013
The IDO pathway mediates immunosuppressive effects through the metabolization of tryptophan (Trp) to kynurenine (Kyn), triggering… Expand
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2012
2012
Prostaglandin E2 (PGE(2)), an abundantly produced lipid messenger in mammalian organisms, has been attributed to possess potent… Expand
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