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IDO Inhibitor NLG919

Known as: GDC-0919, NLG-919, NLG919 
An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon… 
National Institutes of Health

Related topics

Related topics

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NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract 5555: Discovery of DN-016: A highly potent, selective and orally available IDO1 inhibitor for treating cancers
Indoleamine-2,3-dioxygenase (IDO1) is well-recognized as an important target for immunotherapeutic intervention. Growing… 
2018
2018
IDO/TDO Inhibition in Cancer
Elevated tryptophan catabolism in many human tumors occurs due to activation of indoleamine 2,3-dioxygenase-1 (IDO1) or… 
2018
2018
Abstract 2763: Tryptophan metabolism contributes to radiation-induced immune checkpoint reactivation in glioblastoma
Glioblastoma (GBM) is an aggressive brain tumor with limited treatment options. Immune checkpoint inhibitors designed to revert… 
2017
2017
GDC-0919 Modulates Tryptophan Metabolism in Glioblastoma and Enhances Radiation Response
2016
2016
Abstract 3209: CRLX101, an investigational nanoparticle-drug conjugate of camptothecin, demonstrates synergy with immunotherapy agents in preclinical models
CRLX101, an investigational nanoparticle-drug conjugate (NDC) containing the payload camptothecin, is currently being clinically… 
2015
2015
346 Phase 1a study of the safety, pharmacokinetics, and pharmacodynamics of GDC-0919 in patients with recurrent/advanced solid tumors
2014
2014
A Phase I study of NLG919 for adult patients with recurrent advanced solid tumors
Meeting abstracts Clinical Trial Registration Number: [NCT02048709][1] The enzyme Indoleamine 2,3-dioxygenase (IDO1) catalyzes… 
2014
2014
Preclinical assessment of a novel small molecule inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1)
iTeos leverages the science of the LICR to target the metabolism of the tumor microenvironment and develops small-molecule… 
2010
2010
Plangebied Sophiapolder, gemeente Hendrik-Ido-Ambacht; archeologisch vooronderzoek: een inventariserend veldonderzoek (verkennende en karterende fase) : RAAP-RAPPORT 2134
In opdracht van Rijkswaterstaat, dienst Zuid-Holland, heeft RAAP Archeologisch Adviesbureau in januari en mei 2010 een… 
2004
2004
Enzymatische Acetylierung von D-Tryptophan
50%igen U b e r s c h u g Th iony lch lo r id 4 mill bei 50 ~ uild d a n n 2 S td bei R a u m t e m p e r a t u r . Das h i e r d… 
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