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IDN-6556
Known as:
IDN 6556
, IDN6556
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
emricasan
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Carcinogenicity assessment of the pan-caspase inhibitor, emricasan, in Tg.rasH2 mice.
R. Elbekai
,
M. Paranjpe
,
P. Contreras
,
A. Spada
Regulatory toxicology and pharmacology : RTP
2015
Corpus ID: 24859425
2011
2011
The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice.
M. McCall
,
C. Toso
,
+7 authors
A. Shapiro
Surgery
2011
Corpus ID: 44300174
2007
2007
A caspase inhibitor, IDN‐6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia
Niel C. Hoglen
,
D. Anselmo
,
+7 authors
D. Farmer
Liver transplantation
2007
Corpus ID: 11817896
This study examined the efficacy of the caspase inhibitor, IDN‐6556, in a rat model of liver ischemia‐reperfusion injury. Livers…
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2007
2007
Orally-administered caspase inhibitor PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury…
Yoshinobu Ueno
,
T. Ohmi
,
+7 authors
H. Eda
Journal of Pharmacological Sciences
2007
Corpus ID: 32615075
In a mouse model of alpha-Fas-induced acute liver injury, the orally-administered caspase inhibitor PF-03491390 (formerly named…
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2006
2006
Gateways to clinical trials.
M. Bayés
,
X. Rabasseda
,
J. Prous
Methods and Findings in Experimental and Clinical…
2006
Corpus ID: 32748938
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the…
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Review
2005
Review
2005
Caspase inhibitors: a pharmaceutical industry perspective.
S. Linton
Current Topics in Medicinal Chemistry
2005
Corpus ID: 40816709
Caspase inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death, or…
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Review
2004
Review
2004
Characterization of IDN-6556: a liver-targeted caspase inhibitor
N. Hoglen
,
Long-Shiuh Chen
,
C. Fisher
,
B. Hirakawa
,
T. Groessl
,
P. Contreras
2004
Corpus ID: 36912719
The potency, efficacy and pharmacokinetic properties of IDN-6556, a first-in-class caspase inhibitor in clinical trials for the…
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Review
2004
Review
2004
IDN-6556 Idun Pharmaceuticals Inc.
F. Poordad
Current opinion in investigational drugs
2004
Corpus ID: 371595
IDN-6556 is a lead compound from a class of small-molecule caspase protease inhibitors, and is currently under development by…
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2004
2004
66 Oral IDN-6556, An anti-apoptotic caspase inhibitor, lowers aminotransferases in HCV patients
E. Schiff
,
P. Pockros
,
+6 authors
D. Shapiro
2004
Corpus ID: 72664521
Highly Cited
2003
Highly Cited
2003
First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes.
K. Valentino
,
M. Gutierrez
,
R. Sanchez
,
M. Winship
,
D. Shapiro
International journal of clinical pharmacology…
2003
Corpus ID: 6115741
OBJECTIVE To evaluate the safety of IDN-6556, a novel anti-apoptotic pan-caspase inhibitor, administered in single and multiple…
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