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IDN-6556

Known as: IDN 6556, IDN6556 
 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
The combination of a SMAC mimetic and a caspase inhibitor kills AML cells by inducing necroptosis. Giving leukemia a SMAC Second… Expand
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Highly Cited
2015
Highly Cited
2015
Hepatocyte apoptosis, the hallmark of non‐alcoholic steatohepatitis (NASH) contributes to liver injury and fibrosis. Although… Expand
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2011
2011
BACKGROUND Islet transplantation has become a viable option for selected type 1 diabetic patients; however, a significant portion… Expand
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Highly Cited
2007
Highly Cited
2007
Cold ischemia/warm reperfusion (CI/WR) injury remains a problem in liver transplantation. The aim of the current study was to… Expand
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Highly Cited
2007
Highly Cited
2007
Increased rates of apoptosis (programmed cell death) have been demonstrated in many hepatic diseases including chronic hepatitis… Expand
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2007
2007
This study examined the efficacy of the caspase inhibitor, IDN‐6556, in a rat model of liver ischemia‐reperfusion injury. Livers… Expand
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Highly Cited
2004
Highly Cited
2004
Liver injury is characterized by hepatocyte apoptosis and collagen-producing activated hepatic stellate cells (HSC). Hepatocyte… Expand
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Highly Cited
2004
Highly Cited
2004
The potency, efficacy, and pharmacokinetic properties of IDN-6556 (3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino… Expand
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE To evaluate the safety of IDN-6556, a novel anti-apoptotic pan-caspase inhibitor, administered in single and multiple… Expand
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Highly Cited
2003
Highly Cited
2003
Cold ischemia (CI)–warm reperfusion (WR) liver injury remains a problem in liver transplantation. CI‐WR initially causes… Expand
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