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We report the crystal structure of a murine IκBβ·NF-κB p65 homodimer complex. Crystallographic models were determined for two… Expand RelB mediates the constitutive nuclear pool of NF-κB transcriptional activity in myeloid and lymphoid cells, which is believed to… Expand Cystic fibrosis is characterized in the lungs by neutrophil-dominated inflammation mediated significantly by neutrophil elastase… Expand BACKGROUND
Endotoxin is an important factor in the development of acute renal failure related to infection and in acceleration of… Expand ABSTRACT Activation of the macrophage cell line RAW 264.7 with lipopolysaccharide (LPS) and gamma interferon (IFN-γ) induces the… Expand Activation of the nuclear regulatory factor NF-kappaB occurs in the lungs of patients with the acute respiratory distress… Expand IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in… Expand In earlier experiments, exogenous administration of secretory leukocyte protease inhibitor (SLPI) suppressed acute lung injury… Expand In the lesions of atherosclerosis, vascular smooth muscle cells (SMC) display many functions characteristic of cytokine… Expand Extracellular stimuli that activate the transcription factor NF-kappaB cause rapid phosphorylation of the IkappaBalpha inhibitor… Expand