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Hypoxia-Inducible Factor-Proline Dioxygenases

Known as: Prolyl-4-Hydroxylases, HIF, Dioxygenases, Hypoxia-Inducible Factor-Proline, Factor-Proline Dioxygenase, Hypoxia-Inducible 
Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent… 
National Institutes of Health

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EGLN1 protein, humanEGLN2 protein, humanEGLN3 protein, humanEgln1 protein, mouse
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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Review
2010
Review
2010
Mitochondrial regulation of oxygen sensing.
Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through… 
Highly Cited
2008
Highly Cited
2008
Synergystic induction of HIF-1α transcriptional activity by hypoxia and lipopolysaccharide in macrophages
Hypoxia Inducible Factor-1 (HIF-1) is activated by a variety of stimuli, including inflammatory mediators. In this report we… 
2008
2008
The requirement of extracellular signal-related protein kinase pathway in the activation of hypoxia inducible factor 1α in the developing rat brain after hypoxia–ischemia
Hypoxia inducible factor 1α (HIF-1α) is a key regulator of cellular oxygen homeostasis. However, the regulation of HIF-1α in… 
2008
2008
Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury
Reactive oxygen species (ROS) play a crucial role in acute lung injury. Tissue inflammation, the increased vascular permeability… 
Highly Cited
2007
Highly Cited
2007
Tailoring relaxation dispersion experiments for fast-associating protein complexes.
NMR relaxation dispersion spectroscopy is a powerful technique to elucidate the mechanism of protein−protein binding reactions… 
Highly Cited
2006
Highly Cited
2006
Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension.
Hypoxia is a common cause of persistent pulmonary hypertension in the newborn (PPHN), a condition associated with endothelial… 
Review
2006
Review
2006
Recent advances in erythropoietic agents in renal anemia.
2006
2006
Hypoxic preconditioning produces differential expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory enzyme HIF prolyl hydroxylase 2 in neonatal rat brain
Highly Cited
2005
Highly Cited
2005
BMK1/ERK5 Is a Novel Regulator of Angiogenesis by Destabilizing Hypoxia Inducible Factor 1&agr;
Big MAP kinase 1 (BMK1 or ERK5) is a key mediator of endothelial cell (EC) function as shown by impaired embryonic angiogenesis… 
2005
2005
HIF-1α involvement in low temperature and anoxia survival by a freeze tolerant insect
Winter survival for many insect species relies on the ability to endure the freezing of extracellular body fluids. Because… 
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