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Hypoxia-Inducible Factor-Proline Dioxygenases

Known as: Prolyl-4-Hydroxylases, HIF, Dioxygenases, Hypoxia-Inducible Factor-Proline, Factor-Proline Dioxygenase, Hypoxia-Inducible 
Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent… Expand
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and… Expand
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Review
2012
Review
2012
Hypoxia-inducible factors (HIFs) mediate adaptive physiological responses to hypoxia. In human cancers that are accessible for O… Expand
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Highly Cited
2008
Highly Cited
2008
HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an… Expand
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Highly Cited
2007
Highly Cited
2007
The stability and transcriptional activity of the hypoxia-inducible factors (HIFs) are regulated by two oxygen-dependent events… Expand
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Review
2007
Review
2007
Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation… Expand
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Review
2004
Review
2004
Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the von Hippel-Lindau hereditary cancer… Expand
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Highly Cited
2003
Highly Cited
2003
The hypoxia-inducible factors (HIFs) play a central role in oxygen homeostasis. Hydroxylation of one or two critical prolines by… Expand
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Highly Cited
2001
Highly Cited
2001
Mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible… Expand
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Highly Cited
2000
Highly Cited
2000
During hypoxia, hypoxia-inducible factor-1α (HIF-1α) is required for induction of a variety of genes including erythropoietin and… Expand
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Highly Cited
1999
Highly Cited
1999
Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in… Expand
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