Hypoxia-Inducible Factor-Proline Dioxygenases

Known as: Prolyl-4-Hydroxylases, HIF, Dioxygenases, Hypoxia-Inducible Factor-Proline, Factor-Proline Dioxygenase, Hypoxia-Inducible 
Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2018
010020019702018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gene. PKM2, but not PKM1, alters… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Cardiac hypertrophy occurs as an adaptive response to increased workload to maintain cardiac function. However, prolonged cardiac… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Metastasis is a multistep process responsible for most cancer deaths, and it can be influenced by both the immediate… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding angiogenic growth factors, which are secreted by… (More)
  • figure 1
  • table 1
  • table 1
  • table 2
  • table 2
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Hypoxia-inducible factor-1alpha (HIF1alpha) is a central regulator of the cellular response to hypoxia. Prolyl-hydroxylation of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
The hypoxia-inducible factors (HIFs) play a central role in oxygen homeostasis. Hydroxylation of one or two critical prolines by… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table I
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factor (HIF), a heterodimer of HIF-alpha and the… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 6
  • figure 7
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Transcription of the human erythropoietin (EPO) gene is activated in Hep3B cells exposed to hypoxia. Hypoxia-inducible factor 1… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Hypoxia-inducible factor 1 (HIF-1) is a DNA binding activity detected in nuclear extracts from Hep3B cells cultured in 1% O2 but… (More)
Is this relevant?