Hypoxia Inducible Factor Family

Known as: HIF Factor, HIF, Hypoxia Inducible Factor 
A family of basic helix-loop-helix heterodimeric transcription factors that activate gene expression when oxygen levels decrease in the cellular… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Erythropoiesis-stimulating agents (ESAs) increase hemoglobin levels, reduce transfusion requirements, and have been the standard… (More)
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Review
2016
Review
2016
Intratumoral hypoxia (reduced O2 availability) is a common finding in human cancer and leads to increased activity of hypoxia… (More)
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Review
2012
Review
2012
Hypoxia-inducible factors (HIFs) mediate adaptive physiological responses to hypoxia. In human cancers that are accessible for O… (More)
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Review
2010
Review
2010
Oxygen (O(2)) is an essential nutrient that serves as a key substrate in cellular metabolism and bioenergetics. In a variety of… (More)
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Highly Cited
2009
Highly Cited
2009
While hypoxia-inducible factor (HIF) is a major actor in the cell survival response to hypoxia, HIF also is associated with cell… (More)
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Review
2006
Review
2006
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that… (More)
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Highly Cited
2002
Highly Cited
2002
Mammalian cells adapt to hypoxic conditions through a transcriptional response pathway mediated by the hypoxia-inducible factor… (More)
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Highly Cited
2001
Highly Cited
2001
Oxygen-dependent proteolytic destruction of hypoxia-inducible factor-alpha (HIF-alpha) subunits plays a central role in… (More)
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Highly Cited
2000
Highly Cited
2000
The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important mediator of gene expression patterns… (More)
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Highly Cited
1999
Highly Cited
1999
Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in… (More)
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