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Hypoxia-Inducible Factor 1

Known as: HIF1, Hypoxia-Inducible Factor 1 [Chemical/Ingredient], Hypoxia Inducible Factor 1 
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial oxidative phosphorylation (OXPHOS) when oxygen… Expand
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Review
1999
Review
1999
  • G. Semenza
  • Annual review of cell and developmental biology
  • 1999
  • Corpus ID: 25700419
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic-helix-loop-helix-PAS transcription factor consisting of HIF-1 alpha… Expand
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Highly Cited
1999
Highly Cited
1999
Neovascularization and increased glycolysis, two universal characteristics of solid tumors, represent adaptations to a hypoxic… Expand
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Highly Cited
1998
Highly Cited
1998
Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart… Expand
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Highly Cited
1996
Highly Cited
1996
Expression of vascular endothelial growth factor (VEGF) is induced in cells exposed to hypoxia or ischemia. Neovascularization… Expand
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Highly Cited
1996
Highly Cited
1996
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are… Expand
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Highly Cited
1995
Highly Cited
1995
Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for… Expand
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Highly Cited
1995
Highly Cited
1995
Hypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin (Epo) gene transcription in Hep3B cells… Expand
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Highly Cited
1994
Highly Cited
1994
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1… Expand
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Highly Cited
1993
Highly Cited
1993
  • G. Wang, G. Semenza
  • Proceedings of the National Academy of Sciences…
  • 1993
  • Corpus ID: 28961662
Transcription of the human erythropoietin (EPO) gene is activated in Hep3B cells exposed to hypoxia. Hypoxia-inducible factor 1… Expand
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