Hypoxanthine Phosphoribosyltransferase

Known as: HGPRTase, Hypoxanthine Phosphoribosyltransferase [Chemical/Ingredient], Phosphoribosyltransferase, Hypoxanthine-Guanine 
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5… (More)

Topic mentions per year

Topic mentions per year

1965-2017
020406019652017

Papers overview

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Highly Cited
1998
Highly Cited
1998
Various "housekeeping" genes are often used as endogenous controls in gene expression experiments. We have cloned from swine… (More)
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Highly Cited
1998
Highly Cited
1998
Genome-wide demethylation has been suggested to be a step in carcinogenesis. Evidence for this notion comes from the frequently… (More)
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Highly Cited
1996
Highly Cited
1996
A nonhomologous integration vector was used to identify the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl… (More)
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Highly Cited
1990
Highly Cited
1990
The Lesch-Nyhan (LN) syndrome is a genetically lethal human neurological disease that results from mutations that inactivate the… (More)
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Highly Cited
1989
Highly Cited
1989
Embryonic stem cells (derived from 129/Ola mice) containing a mutant hypoxanthine phosphoribosyltransferase gene that had been… (More)
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Highly Cited
1987
Highly Cited
1987
Embryonal stem (ES) cell lines, established in culture from peri-implantation mouse blastocysts, can colonize both the somatic… (More)
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1986
1986
The human hypoxanthine phosphoribosyltransferase (HPRT) gene has been characterized by molecular cloning, mapping, and DNA… (More)
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1984
1984
The wild-type mouse hypoxanthine phosphoribosyltransferase (HPRT; IMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) gene… (More)
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1984
1984
To explore the role of DNA methylation in maintaining dosage compensation of X chromosome-linked genes and in regulating the… (More)
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1984
1984
Previous theoretical considerations and some experimental data have suggested a role for DNA methylation in the maintenance of… (More)
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