Hypomethylation

Known as: DNA Hypomethylation 
An epigenetic process that either inhibits DNA methyltransferase activity or promotes DNA demethylase activity, and results in a net loss of 5… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of… (More)
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Highly Cited
2009
Highly Cited
2009
Aberrant DNA hypermethylation contributes to myeloid leukemogenesis by silencing structurally normal genes involved in… (More)
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Highly Cited
2009
Highly Cited
2009
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… (More)
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Highly Cited
2007
Highly Cited
2007
The hypothesis of fetal origins of adult disease posits that early developmental exposures involve epigenetic modifications, such… (More)
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Highly Cited
2005
Highly Cited
2005
Embryonic stem (ES) cells are important tools in the study of gene function and may also become important in cell therapy… (More)
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Highly Cited
2005
Highly Cited
2005
Tamoxifen, a selective oestrogen receptor modulator, has been used in the treatment of all stages of hormone-responsive breast… (More)
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Highly Cited
2003
Highly Cited
2003
To investigate the relationship between DNA hypomethylation and gene overexpression in pancreatic cancer, we analyzed the… (More)
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Highly Cited
1996
Highly Cited
1996
A number of aberrant morphological phenotypes were noted during propagation of the Arabidopsis thaliana DNA hypomethylation… (More)
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Highly Cited
1995
Highly Cited
1995
We have used a combination of genetics and pharmacology to assess the effects of reduced DNA methyltransferase activity on ApcMin… (More)
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Highly Cited
1993
Highly Cited
1993
The bcl-2 gene becomes transcriptionally deregulated in the majority of low-grade non-Hodgkin lymphomas as a result of t(14;18… (More)
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