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Hypomethylation

Known as: DNA Hypomethylation 
An epigenetic process that either inhibits DNA methyltransferase activity or promotes DNA demethylase activity, and results in a net loss of 5… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the metabolism of the essential amino acid… Expand
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Review
2018
Review
2018
Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells facilitating cancer development and… Expand
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Highly Cited
2009
Highly Cited
2009
Aberrant DNA hypermethylation contributes to myeloid leukemogenesis by silencing structurally normal genes involved in… Expand
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Highly Cited
2007
Highly Cited
2007
The hypothesis of fetal origins of adult disease posits that early developmental exposures involve epigenetic modifications, such… Expand
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Highly Cited
2003
Highly Cited
2003
Human tumors often display changes in DNA methylation, including both genome-wide hypomethylation and site-specific… Expand
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Highly Cited
2003
Highly Cited
2003
Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of… Expand
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Highly Cited
2000
Highly Cited
2000
S-Adenosylmethionine andS-adenosylhomocysteine (SAH), as the substrate and product of essential cellular methyltransferase… Expand
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Highly Cited
1998
Highly Cited
1998
Genome-wide demethylation has been suggested to be a step in carcinogenesis. Evidence for this notion comes from the frequently… Expand
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Highly Cited
1995
Highly Cited
1995
We have used a combination of genetics and pharmacology to assess the effects of reduced DNA methyltransferase activity on ApcMin… Expand
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Highly Cited
1985
Highly Cited
1985
The methylation state of DNA from human colon tissue displaying neoplastic growth was determined by means of restriction… Expand
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