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Hypomethylation Therapy

Known as: Hypomethylating Agent-Based Therapy, Hypomethylating Therapy 
Therapies that target the activity of DNA methyltransferases. Hypomethylating agents, including azacitidine and decitabine, have been used in the… Expand
National Institutes of Health

Papers overview

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2016
2016
Although hypomethylating therapy (HMT) is the first line therapy in higher-risk myelodysplastic syndromes (MDS), predicting… Expand
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2014
2014
The introduction of reduced-intensity conditioning (RIC) regimens made it possible to offer allogeneic hematopoietic cell… Expand
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2012
2012
In a Phase I/II clinical trial, 13 higher risk red blood cell-dependent myelodysplastic syndrome (MDS) patients unresponsive to… Expand
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2011
2011
Abstract 461 Aberrant DNA methylation is a hallmark of myelodysplastic syndromes (MDS), MDS/myeloproliferative neoplasms (MDS… Expand
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Review
2011
Review
2011
DNA methylation and its influence on gene expression are key in understanding cancer pathogenesis. Even though it is becoming… Expand
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Review
2009
Review
2009
Allogeneic hematopoietic SCT (allo-HCT) is the only curative therapy for myelodysplastic syndrome (MDS). Numerous myeloablative… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Outcome of patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) with chromosome 5… Expand
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Highly Cited
2009
Highly Cited
2009
Decitabine is a hypomethylating agent with activity in myelodysplastic syndrome (MDS). It is largely unknown whether treatment… Expand
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2008
2008
Silver–Russell syndrome (SRS) is a clinically and genetically heterogeneous syndrome characterized by severe pre and postnatal… Expand
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Highly Cited
2007
Highly Cited
2007
RNA interference (RNAi) is implicated in maintaining tandem DNA arrays as constitutive heterochromatin. We used chromatin… Expand
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