Hyperplasia of the Leydig cells

Known as: Leydig cell hyperplasia 
Hypertrophy or overdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone. [HPO:probinson]

Topic mentions per year

Topic mentions per year

1947-2018
051019472017

Papers overview

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Highly Cited
2004
Highly Cited
2004
The possibility that exposures to environmental agents are associated with reproductive disorders in human populations has… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND The disorders comprising human 'testicular dysgenesis syndrome' (TDS) may be increasing in incidence. TDS originates… (More)
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Highly Cited
2002
Highly Cited
2002
Adult male rats previously exposed on gestation days (GD) 12-21 to di(n-butyl) phthalate (DBP) have reproductive tract… (More)
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Highly Cited
2000
Highly Cited
2000
Phthalate esters (PE) such as DEHP are high production volume plasticizers used in vinyl floors, food wraps, cosmetics, medical… (More)
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Highly Cited
1999
Highly Cited
1999
It is well established that spermatogenesis is controlled by gonadotrophins and testosterone. However, a role for estrogens in… (More)
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1998
1998
Strong overexpression of anti-Müllerian hormone (AMH) in transgenic mice leads to incomplete fetal virilization and decreased… (More)
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Highly Cited
1995
Highly Cited
1995
Ammonium perfluorooctanoate (C8) produced a dose-dependent increase in Leydig cell adenomas in Crl:CD BR (CD) rats fed 0, 30, or… (More)
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Highly Cited
1994
Highly Cited
1994
To investigate the role of Müllerian-inhibiting substance (MIS) in mammalian sexual development, we generated MIS-deficient mice… (More)
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1993
1993
In a previously conducted 2-year study, a concentration-dependent increase in Leydig cell adenomas was observed in Crl:CD BR(CD… (More)
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Highly Cited
1993
Highly Cited
1993
Familial male precocious puberty (FMPP) is a gonadotropin-independent disorder that is inherited in an autosomal dominant, male… (More)
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