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Hyperlysinemias

Known as: Familial Hyperlysinemia, Lysine:Alpha Ketoglutarate Reductase Deficiency, L-Lysine:NAD-Oxido-Reductase Deficiencies 
A group of inherited metabolic disorders which have in common elevations of serum LYSINE levels. Enzyme deficiencies of alpha-aminoadipic… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
The global burden of neurodegenerative disorders has increased substantially over the past 2 decades due to rising rates of… Expand
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Review
2014
Review
2014
Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the… Expand
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Review
2014
Review
2014
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both… Expand
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Highly Cited
2011
Highly Cited
2011
Protein post-translational modifications (PTMs) at the lysine residue, such as lysine methylation, acetylation, and… Expand
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Highly Cited
2010
Highly Cited
2010
Genetic deletion of the mitochondrial deacetylase sirtuin-3 (Sirt3) results in increased mitochondrial superoxide, a tumor… Expand
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Highly Cited
2010
Highly Cited
2010
The microRNA miR-137 represses expression of Ezh2, a histone methyltransferase, which in turn alters the epigenetic architecture… Expand
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Highly Cited
2007
Highly Cited
2007
Asifa Akhtar, David Allis, Genevieve Almouzni, Robin Allshire, Tony Annunziato, Trevor Archer, Miguel Beato, Peter Becker… Expand
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Highly Cited
2004
Highly Cited
2004
We recently used a positional cloning approach to identify a nonconservative lysine to alanine substitution (K232A) in the bovine… Expand
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Highly Cited
1999
Highly Cited
1999
Histone acetylation is important in chromatin remodelling and gene activation. Nearly all known histone-acetyltransferase (HAT… Expand
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Highly Cited
1999
Highly Cited
1999
Diatom cell walls are regarded as a paradigm for controlled production of nanostructured silica, but the mechanisms allowing… Expand
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