Hydromorphone

Known as: (-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one, Dihydromorphinone, 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one 
The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1952-2017
05010019522016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
BACKGROUND The use of prescription opioid medications has increased greatly in the United States during the past two decades; in… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2008
Highly Cited
2008
SUMMARY OF CONSENSUS: 1. The use of opioids in cancer pain: The criteria for selecting analgesics for pain treatment in the… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Rationale: The availability of the highly selective and specific kappa opioid agonist enadoline provides an opportunity to… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
2001
2001
BACKGROUND The disposition kinetics of hydromorphone generally necessitates oral administration every 4 h of the conventional… (More)
Is this relevant?
1997
1997
This study investigated the analgesic effects of three intravenous bolus doses of hydromorphone (10, 20, 40 micrograms/kg) on… (More)
Is this relevant?
1996
1996
A morphine to hydromorphone equivalence ratio of 7:1 has become the accepted standard, but evidence supporting it comes from… (More)
Is this relevant?
1996
1996
Although patient-controlled analgesia (PCA) pumps have been in use for more than a decade, the optimal PCA analgesic has yet to… (More)
Is this relevant?
1994
1994
Standard measures of subjective and discriminative effects of drugs were compared in 5 human volunteers. Subjects responded on a… (More)
Is this relevant?
1994
1994
Six opioid-dependent in-patients were maintained on daily sublingual doses of buprenorphine at 2, 6, and 12 mg/day for five days… (More)
Is this relevant?
1993
1993
The contribution of cytochrome P450 2D6 (CYP2D6) to the formation of hydrocodone's active metabolite, hydromorphone, was examined… (More)
Is this relevant?