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Humoral hypercalcemia of malignancy (disorder)

Known as: HYPERCALCEMIA OF MALIGNANCY, hypercalcaemia of malignancy, Humoral Hypercalcemia Of Malignancy 
Hypercalcemia generally develops as a late complication of malignancy; its appearance has grave prognostic significance. It remains unclear, however… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

HypercalcemiaParaneoplastic Syndromes
Ovarian Small Cell Carcinoma, Hypercalcemic TypePTHLH protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy.
The extracellular calcium-sensing receptor (CaR) plays a key role in the defense against hypercalcemia by "sensing" extracellular… 
Highly Cited
2001
Highly Cited
2001
Pathophysiology of X-linked hypophosphatemia, tumor-induced osteomalacia, and autosomal dominant hypophosphatemia: a perPHEXing problem.
Proximal tubular reabsorption of phosphate is a major determinant of the serum phosphate concentration (1). The presence of many… 
Review
2001
Review
2001
Hypercalcemia of malignancy--new insights into an old syndrome.
Hypercalcemia is a common paraneoplastic syndrome. Tumors induce hypercalcemia by a local mechanism associated with the tumor's… 
Highly Cited
1995
Highly Cited
1995
Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) has been shown to be the major mediator of hypercalcemia of malignancy, but may also exert effects on… 
Highly Cited
1991
Highly Cited
1991
Immunohistologic evaluation of parathyroid hormone‐related protein in human lung cancer and normal tissue with newly developed monoclonal antibody
With a newly developed monoclonal anti‐PTHrP antibody, 4B3, the immunohistochemical localization of the parathyroid hormone… 
Highly Cited
1991
Highly Cited
1991
Structural requirements for the action of parathyroid hormone‐related protein (PTHrP) on bone resorption by isolated osteoclasts
Parathyroid hormone‐related protein (PTHrP) plays a major role in the syndrome of humoral hypercalcemia of malignancy (HHM) by… 
Highly Cited
1990
Highly Cited
1990
Structure of the mouse gene encoding parathyroid hormone-related peptide.
Highly Cited
1985
Highly Cited
1985
Hypercalcemia in pheochromocytoma. Evidence for a novel mechanism.
A child with a pheochromocytoma had hypercalcemia but no evidence for excessive parathyroid hormone secretion from the… 
Highly Cited
1985
Highly Cited
1985
EGF receptor antiserum inhibits bone resorbing activity produced by a rat Leydig cell tumor associated with the humoral hypercalcemia of malignancy.
The humoral hypercalcemia of malignancy (HHM) is a syndrome caused by tumor cells releasing unknown circulating factors which… 
Highly Cited
1981
Highly Cited
1981
Urinary and nephrogenous adenosine 3',5'-monophosphate in the hypercalcemia of malignancy.
Plasma cAMP concentration (PcAMP) and urinary cAMP excretion (UcAMP) were determined in 91 patients with hypercalcemia and… 
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