Human interactome

The human interactome is the set of protein–protein interactions (the interactome) that occur in human cells. The sequencing of reference genomes, in… (More)
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2016
2016
MOTIVATION Many diseases are related by shared associated molecules and pathways, exhibiting comorbidities and common phenotypes… (More)
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2015
2015
According to the disease module hypothesis the cellular components associated with a disease segregate in the same neighborhood… (More)
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2014
2014
We have long moved past the one-gene-one-function concept originally proposed by Beadle and Tatum back in 1941; but the full… (More)
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Highly Cited
2011
Highly Cited
2011
Supplementary Figure 1 The conventional approach for sequencing large numbers of ORF pairs resulting from high-throughput Y2H… (More)
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Highly Cited
2009
Highly Cited
2009
The PIPs database (http://www.compbio.dundee.ac.uk/www-pips) is a resource for studying protein-protein interactions in human. It… (More)
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2009
2009
Human protein interaction maps have become important tools of biomedical research for the elucidation of molecular mechanisms and… (More)
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Highly Cited
2007
Highly Cited
2007
Systematic mapping of protein-protein interactions has become a central task of functional genomics. To map the human interactome… (More)
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Highly Cited
2006
Highly Cited
2006
MOTIVATION The study of interactomes, or networks of protein-protein interactions, is increasingly providing valuable information… (More)
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2006
2006
MOTIVATION Large-scale mappings of protein-protein interactions have started to give us new views of the complex molecular… (More)
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Highly Cited
2004
Highly Cited
2004
One possible path towards understanding the biological function of a target protein is through the discovery of how it interfaces… (More)
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