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Human Combinatorial Antibody Library-based Monoclonal Antibody VAY736

Known as: HuCAL-based Antibody VAY736, VAY736 
A fully human combinatorial antibody library (HuCAL)-derived monoclonal antibody targeting the B-cell-activating factor receptor (BAFF-R), with… Expand
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
Objectives To evaluate the efficacy and safety of ianalumab (VAY736), a B cell-depleting, B cell activating factor receptor… Expand
2019
2019
Blocking BAFF-R early in ALL promotes killing of leukemic cells. However, if given at later disease stages, efficacy is limited… Expand
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2018
2018
  • T. Dörner, B. Fisher, +7 authors A.M. Wright
  • SLE, Sjögren’s and APS – clinical aspects (other…
  • 2018
  • Corpus ID: 81219716
Background According to international consensus, disease activity in primary Sjögren’s syndrome (pSS) patients shall be scored… Expand
2017
2017
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting wide range of systems including the… Expand
2017
2017
Background Overexpression of B cell activating factor (BAFF) contributes to the pathogenesis of primary Sjögren's syndrome (pSS… Expand
2017
2017
Background Overexpression of B cell activating factor (BAFF) in salivary glands contributes to the pathogenesis of primary Sj… Expand
2016
2016
Background VAY736 is a novel, defucosylated, human IgG1 mAb targeting the receptor for B cell activating Factor of the TNF family… Expand