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Human Adenovirus Type 5 Early Region 1

Known as: Ad5E1 
A region of the adenovirus type 5 genome that contains the transforming early genes E1A and E1B.
National Institutes of Health

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AdenovirusesVirus Physiological Phenomena

Papers overview

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2008
2008
CD4+ T‐cell‐dependent tumour rejection in an immune‐privileged environment requires macrophages
Although intraocular tumours reside in an immune‐privileged site, they can circumvent immune privilege and undergo rejection… 
2003
2003
Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the Vβ8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4…
Adenovirus vectors are increasingly being used for genetic vaccination and may prove highly suitable for intervention in… 
Highly Cited
2003
Highly Cited
2003
Role of TRAIL and IFN-γ in CD4+ T Cell-Dependent Tumor Rejection in the Anterior Chamber of the Eye 1
Although the anterior chamber of the eye expresses immune privilege, some ocular tumors succumb to immune rejection. Previous… 
Highly Cited
1999
Highly Cited
1999
Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial
We conducted a phase 1 trial of direct injection of an E1,E3-deleted adenovirus encoding interleukin-2 (AdCAIL-2) into… 
Highly Cited
1998
Highly Cited
1998
Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells.
Synthetic peptide-based vaccines have been shown to induce potent protective and therapeutic T cell-mediated immunity in… 
Highly Cited
1998
Highly Cited
1998
A double recombinant adenovirus expressing the costimulatory molecule B7-1 (murine) and human IL-2 induces complete tumor regression in a murine breast adenocarcinoma model.
Tumors that express tumor-specific antigens can maintain growth in an immunocompetent organism. Current hypotheses tend toward T… 
Highly Cited
1996
Highly Cited
1996
Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors.
CTL can play an important role in the defense against tumors. Protective CTL-mediated immunity can be established in animal tumor… 
Highly Cited
1996
Highly Cited
1996
Protective antitumor immunity induced by immunization with completely allogeneic tumor cells.
We have shown previously that immunization of B6 mice (H-2b) with tumor cells of B6 origin transformed by the human adenovirus… 
Highly Cited
1995
Highly Cited
1995
An adenovirus type 5 early region 1B-encoded CTL epitope-mediating tumor eradication by CTL clones is down-modulated by an activated ras oncogene.
Mouse embryo cells (C57BL/6, H-2b) transformed by the E1A and E1B genes of adenovirus type 5 (Ad5E1 MEC) are highly immunogenic… 
Highly Cited
1986
Highly Cited
1986
Adenovirus E1A‐mediated regulation of class I MHC expression.
Expression of class I MHC transplantation antigens has been shown to be reduced in baby rat kidney (BRK) cells transformed by… 
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