FAQ

Human Adenovirus Type 5 Early Region 1

Known as: Ad5E1 
A region of the adenovirus type 5 genome that contains the transforming early genes E1A and E1B.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2011
012319862011

Related topics

Related topics

2 relations
AdenovirusesVirus Physiological Phenomena

Related mentions per year

Related mentions per year

1955-2018
1960198020002020
Human Adenovirus Type 5 Early Region 1
Adenoviruses
Virus Physiological Phenomena

Papers overview

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2008
2008
CD4+ T-cell-dependent tumour rejection in an immune-privileged environment requires macrophages.
Although intraocular tumours reside in an immune-privileged site, they can circumvent immune privilege and undergo rejection… (More)
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2007
2007
CD8+ T cells circumvent immune privilege in the eye and mediate intraocular tumor rejection by a TNF-alpha-dependent mechanism.
Although intraocular tumors reside in an immune-privileged environment, T cells can circumvent immune privilege and mediate tumor… (More)
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2007
2007
Ocular immune privilege is circumvented by CD4+ T cells, leading to the rejection of intraocular tumors in an IFN-{gamma}-dependent manner.
Although intraocular tumors reside in an immune-privileged site, they can circumvent immune privilege and undergo rejection… (More)
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2003
2003
Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the V beta 8.2 TCR is disrupted by coadministration with vectors expressing either…
Adenovirus vectors are increasingly being used for genetic vaccination and may prove highly suitable for intervention in… (More)
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1999
1999
Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial
We conducted a phase 1 trial of direct injection of an E1,E3-deleted adenovirus encoding interleukin-2 (AdCAIL-2) into… (More)
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1998
1998
A double recombinant adenovirus expressing the costimulatory molecule B7-1 (murine) and human IL-2 induces complete tumor regression in a murine breast adenocarcinoma model.
Tumors that express tumor-specific antigens can maintain growth in an immunocompetent organism. Current hypotheses tend toward T… (More)
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Highly Cited
1998
Highly Cited
1998
Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells.
Synthetic peptide-based vaccines have been shown to induce potent protective and therapeutic T cell-mediated immunity in… (More)
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Highly Cited
1996
Highly Cited
1996
Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors.
CTL can play an important role in the defense against tumors. Protective CTL-mediated immunity can be established in animal tumor… (More)
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1996
1996
The adenovirus E1A-associated 300 kDa adaptor protein counteracts the inhibition of the collagenase promoter by E1A and represses transformation.
Adenovirus E1A proteins modulate the expression of a large variety of genes in transformed cells by either stimulating or… (More)
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1995
1995
An adenovirus type 5 early region 1B-encoded CTL epitope-mediating tumor eradication by CTL clones is down-modulated by an activated ras oncogene.
Mouse embryo cells (C57BL/6, H-2b) transformed by the E1A and E1B genes of adenovirus type 5 (Ad5E1 MEC) are highly immunogenic… (More)
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