Human Adenovirus Type 5 Early Region 1

Although intraocular tumours reside in an immune-privileged site, they can circumvent immune privilege and undergo rejection… Expand

Although intraocular tumors reside in an immune-privileged environment, T cells can circumvent immune privilege and mediate tumor… Expand

Although the anterior chamber of the eye expresses immune privilege, some ocular tumors succumb to immune rejection. Previous… Expand

We conducted a phase 1 trial of direct injection of an E1,E3-deleted adenovirus encoding interleukin-2 (AdCAIL-2) into… Expand

Tumors that express tumor-specific antigens can maintain growth in an immunocompetent organism. Current hypotheses tend toward T… Expand

Synthetic peptide-based vaccines have been shown to induce potent protective and therapeutic T cell-mediated immunity in… Expand

CTL can play an important role in the defense against tumors. Protective CTL-mediated immunity can be established in animal tumor… Expand

We have shown previously that immunization of B6 mice (H-2b) with tumor cells of B6 origin transformed by the human adenovirus… Expand

Adenovirus E1A proteins modulate the expression of a large variety of genes in transformed cells by either stimulating or… Expand

Mouse embryo cells (C57BL/6, H-2b) transformed by the E1A and E1B genes of adenovirus type 5 (Ad5E1 MEC) are highly immunogenic… Expand