Homologous Recombination Deficiency

Known as: HRD 
A DNA repair abnormality caused by mutations in one or more genes that are involved in homologous recombination repair. Deficient homologous… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
PURPOSE BRCA1/2-mutated and some sporadic triple-negative breast cancers (TNBC) have DNA repair defects and are sensitive to DNA… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Review
2016
Review
2016
The discovery that PARP inhibitors block an essential pathway of DNA repair in cells harbouring a BRCA mutation has opened up a… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
2014
2014
Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA damage… (More)
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Background:Defects in BRCA1, BRCA2, and other members of the homologous recombination pathway have potential therapeutic… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
2011
2011
BACKGROUND Tumors with homologous recombination deficiency (HRD), such as BRCA1-associated breast cancers, are not able to… (More)
  • table 2
  • figure 1
  • table 3
  • table 4
  • table 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Freshwater is a limited and dwindling global resource; therefore, efficient water use is required for food crops that have high… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
This paper explores the definitions and usage of competence, especially in the context of training and development initiatives in… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Endoplasmic reticulum (ER)-associated degradation (ERAD) is required for ubiquitin-mediated destruction of numerous proteins… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The HRD real-time wind analysis system is currently undergoing evaluation in the operational forecasting environment of the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R), a key enzyme of sterol synthesis, is an integral membrane protein of the… (More)
Is this relevant?