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Homogentisate 1,2-dioxygenase

Known as: Homogentisate 1,2 Dioxygenase, Oxidase, Homogentisic Acid, Homogentisate Dioxygenase 
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the… 
National Institutes of Health

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AlkaptonuriaHGD geneIn BloodProcess of secretion

Papers overview

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2013
2013
First report of HGD mutations in a Chinese with alkaptonuria.
2008
2008
[Arthroplasty for the treatment of joint degeneration caused by ochronosis in two cases].
Ochronosis is a rare metabolic disease caused by the deficiency of the homogentisic acid oxidase enzyme. With increasing age… 
2007
2007
Aortic stenosis in cardiovascular ochronosis
Alkaptonuria (endogenous ochronosis) is a rare metabolic disorder caused by a deficiency of homogentisic acid oxidase, an enzyme… 
2005
2005
Early detection of alkaptonuria.
Alkaptonuria is a rare disorder of metabolism characterized by deficiency of homogentisic acid oxidase. This leads to the… 
2003
2003
[Case report of a patient with ochronosis and arthroplasty of the hip and both knees].
Alkaptonuria is a rare hereditary metabolic disorder characterised by absence of the enzyme homogentisic acid oxidase. As a… 
1970
1970
Alkaptonuria and Gilbert's syndrome. Report of two affected siblings and hepatic ultrastructure in one sibling.
1966
1966
Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens.
1963
1963
Purification of mammalian homogentisate oxidase and evidence for the existence of ferrous mercaptans in the active center.
1960
1960
Oxygen transfer by the homogentisate oxidase of rat liver.
1957
1957
Role of Enzymatic Adaptation in Production of Experimental Alkaptonuria.∗
  • E. LinW. Knox
  • Proceedings of the Society for Experimental…
  • 1957
  • Corpus ID: 35379119
Summary Experimental alkaptonuria of rats maintained on a high tyrosine diet is associated with an increased ratio of activity of… 
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