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Homeobox Protein Hox-D13

Known as: HOXD13, Homeobox Protein Hox-4I 
Homeobox protein Hox-D13 (343 aa, ~36 kDa) is encoded by the human HOXD13 gene. This protein plays a role in transcriptional modulation that mediates… Expand
National Institutes of Health

Related topics

Related topics

9 relations
Cell NucleusDNA-Binding ProteinsGenes, RegulatorHOXD13 gene
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Papers overview

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Highly Cited
2008
Highly Cited
2008
Identification of a HOXD13 mutation in a VACTERL patient.
VACTERL acronym is assigned to a non-random association of malformations in humans with poorly known etiology. It is comprised of… Expand
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Highly Cited
2007
Highly Cited
2007
Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome.
HOXD13, the homeobox-containing gene located at the most 5' end of the HOXD cluster, plays a critical role in limb development… Expand
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Highly Cited
2006
Highly Cited
2006
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.
Aberrant methylation of promoter CpG islands (CGI) is involved in silencing of tumor suppressor genes and is also a potential… Expand
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Highly Cited
2006
Highly Cited
2006
Microarray analysis reveals differential gene expression patterns in tumors of the pineal region.
Several types of tumors are known to originate from the pineal region, among them pineal parenchymal tumors (PPTs) and papillary… Expand
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2006
2006
Hoxd13 and Hoxa13 directly control the expression of the EphA7 Ephrin tyrosine kinase receptor in developing limbs.
Hoxa and Hoxd genes, related to the Drosophila Abd-B gene, display regionally restricted expression patterns and are necessary… Expand
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Highly Cited
2005
Highly Cited
2005
Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
AbdB-like HOX proteins form DNA-binding complexes with the TALE superclass proteins MEIS1A and MEIS1B, and trimeric complexes… Expand
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2005
2005
Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.
Hox genes encode transcription factors that regulate the morphogenesis of developing embryos. In mammals, knowledge of the… Expand
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1998
1998
A new spontaneous mouse mutation of Hoxd13 with a polyalanine expansion and phenotype similar to human synpolydactyly.
Human synpolydactyly (SPD) is an inherited congenital limb malformation caused by mutations in the HOXD13 gene. Heterozygotes are… Expand
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1998
1998
Deletions in HOXD13 segregate with an identical, novel foot malformation in two unrelated families.
Synpolydactyly (SPD) is a dominantly inherited congenital limb malformation consisting of 3/4 syndactyly in the hands and 4/5… Expand
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Highly Cited
1996
Highly Cited
1996
Altered Growth and Branching Patterns in Synpolydactyly Caused by Mutations in HOXD13
Hox genes regulate patterning during limb development. It is believed that they function in the determination of the timing and… Expand
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