Histone-Lysine N-Methyltransferase SETD2, Human

Known as: Set2 protein, human, SETD2 protein, human, HIF-1 
Histone-lysine methyltransferase SETD2 (2564 aa, ~288 kDa) is encoded by the human SETD2 gene. This soluble, nuclear protein may play a role in… (More)
National Institutes of Health

Papers overview

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Review
2016
Review
2016
In the past decade important progress has been made in our understanding of the epigenetic regulatory machinery. It has become… (More)
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Highly Cited
2014
Highly Cited
2014
Modulating chromatin through histone methylation orchestrates numerous cellular processes. SETD2-dependent trimethylation of… (More)
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Highly Cited
2014
Highly Cited
2014
Acute leukemia characterized by chromosomal rearrangements requires additional molecular disruptions to develop into full-blown… (More)
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Highly Cited
2014
Highly Cited
2014
Comprehensive sequencing of human cancers has identified recurrent mutations in genes encoding chromatin regulatory proteins. For… (More)
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Highly Cited
2014
Highly Cited
2014
Histone modifications establish the chromatin states that coordinate the DNA damage response. In this study, we show that SETD2… (More)
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Highly Cited
2013
Highly Cited
2013
Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade… (More)
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Highly Cited
2013
Highly Cited
2013
Histone H3 of nucleosomes positioned on active genes is trimethylated at Lys36 (H3K36me3) by the SETD2 (also termed KMT3A/SET2 or… (More)
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2012
2012
Epigenetic regulation is involved in numerous physiological and pathogenic processes. Among the key regulators that orchestrate… (More)
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Highly Cited
2011
Highly Cited
2011
The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor gene in clear cell carcinoma (ccRCC), the… (More)
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Highly Cited
2010
Highly Cited
2010
Sporadic clear cell renal cell carcinoma (cRCC) is genetically characterized by the recurrent loss of the short arm of chromosome… (More)
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