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Histone-Lysine N-Methyltransferase EZH2 Inhibitor GSK2816126

Known as: EZH2 Inhibitor GSK2816126, GSK2816126 
A small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone-lysine N-methyltransferase EZH2, with potential… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

Papers overview

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2020
2020
EZH2-activating mutation: no reliable indicator for efficacy of methyltransferase inhibitors
Abstract EZH2 gain of function mutations (EZH2GOFmu) has been implicated in the pathogenesis of B-non-Hodgkin lymphoma. The EZH2… 
2020
2020
Abstract OI: Novel non-canonical functions of EZH2 in triple negative breast cancer
Patients with distant metastasis at the time of diagnosis have significantly worse prognosis. Triple negative breast carcinomas… 
2017
2017
DUAL INHIBITION OF EZH2 AND HDAC IS SYNERGISTIC IN EZH2 DYSREGULATED LYMPHOMAS
rubicin, epirubicin, vinblastine, etoposide, paclitaxel, and topotecan. RTI‐79's PK characteristics are similar to rifabutin and… 
2016
2016
Abstract 4481: Phosphorylation regulates EZH2 neoplastic functions in triple-negative breast cancer
Background: Triple negative (estrogen receptor, progesterone receptor, HER2-neu negative) breast cancers (TNBC) comprise 15% of… 
2016
2016
NKTL. When investigating coimmunoprecipitates, they observed an association of both proteins. Pharmacologic inhibition of the JAK/STAT5 signaling pathway led to an increased H3K27 trimethylation…
  • 2016
  • Corpus ID: 207760052
coimmunoprecipitates, they observed an association of both proteins. Pharmacologic inhibition of the JAK/STAT5 signaling pathway… 
2014
2014
Replikacija DNA u sekundarnom limfnom tkivu
Germinativni centri (GC) folikula sekundarnog limfnog tkiva iznimno su dinamican okolis gdje B‐limfociti prolaze klonalnu… 
2013
2013
Functional Defects In Neutrophils Derived From Ezh2 Null Mice
Introduction We investigate the role of Ezh2 in neutrophil function using murine progenitor cells differentiated into neutrophils… 
2013
2013
EZH2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
2010
2010
EZH2 inhibitors在lapatinib處理之HER2low/neg乳癌細胞抑制轉移作用之探討
Breast cancer is a very common cancer around the world and overexpression of HER2 is found in 20-25% of the patients. HER2 is a… 
2007
2007
PRDM 5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer
Purpose: PR (PRDI-BF1and RIZ) domain proteins (PRDM) are a subfamily of the kruppel-like zinc finger gene products that play key… 
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