Histone Deacetylase Complexes

Dynamic regulation of diverse nuclear processes is intimately linked to covalent modifications of chromatin. Much attention has… Expand

Here we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST-HDAC is… Expand

Transcription repression mediated through histone deacetylase (HDAC) complexes is widespread, and mechanisms by which HDAC… Expand

ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation represent mechanisms to alter nucleosome… Expand

Mammalian DNA is methylated at many CpG dinucleotides. The biological consequences of methylation are mediated by a family of… Expand

Germ-line mutations in the BRCA1 tumor-suppressor gene are associated with an increased susceptibility to breast and ovarian… Expand

CBF1 is a member of the CSL family of DNA binding factors, which mediate either transcriptional repression or transcriptional… Expand

Cytosine residues in the sequence 5′CpG (cytosine–guanine) are often postsynthetically methylated in animal genomes. CpG… Expand

ABSTRACT Nuclear receptor corepressor (CoR)-histone deacetylase (HDAC) complex recruitment is indispensable for the biological… Expand

Increased histone acetylation has been correlated with increased transcription, and regions of heterochromatin are generally… Expand