Histone Deacetylase Complexes

Dynamic regulation of diverse nuclear processes is intimately linked to covalent modifications of chromatin. Much attention has… (More)

Here we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST-HDAC is… (More)

Transcription repression mediated through histone deacetylase (HDAC) complexes is widespread, and mechanisms by which HDAC… (More)

Mammalian DNA is methylated at many CpG dinucleotides. The biological consequences of methylation are mediated by a family of… (More)

ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation represent mechanisms to alter nucleosome… (More)

Accumulative evidence suggests that more than 20 neuron-specific genes are regulated by a transcriptional cis-regulatory element… (More)

Germ-line mutations in the BRCA1 tumor-suppressor gene are associated with an increased susceptibility to breast and ovarian… (More)

CBF1 is a member of the CSL family of DNA binding factors, which mediate either transcriptional repression or transcriptional… (More)

Nuclear receptor corepressor (CoR)-histone deacetylase (HDAC) complex recruitment is indispensable for the biological activities… (More)

Increased histone acetylation has been correlated with increased transcription, and regions of heterochromatin are generally… (More)