Histone Deacetylase 8

Known as: Histone Deacetylase-Like 1, HD8, HDAC8 
Histone deacetylase 8 (377 aa, ~24 kDa) is encoded by the human HDAC8 gene. This protein is involved in the deacetylation of core histones.
National Institutes of Health

Papers overview

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2013
2013
Mutation of the p53 gene is the most common genetic alteration in human cancer and contributes to malignant process by enhancing… (More)
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2010
2010
Histone deacetylases are key regulators of gene expression and have recently emerged as important therapeutic targets for cancer… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The effects of pan-histone deacetylase (HDAC) inhibitors on cancer cells have shown that HDACs are involved in… (More)
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Highly Cited
2007
Highly Cited
2007
Histone deacetylases (HDACs)-an enzyme family that deacetylates histones and non-histone proteins-are implicated in human… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation that is greater in… (More)
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Highly Cited
2004
Highly Cited
2004
Modulation of the acetylation state of histones plays a pivotal role in the regulation of gene expression. Histone deacetylases… (More)
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Highly Cited
2004
Highly Cited
2004
Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress… (More)
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Highly Cited
2003
Highly Cited
2003
Histone deacetylases (HDACs) represent an expanding family of protein modifying-enzymes that play important roles in cell… (More)
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Review
2001
Review
2001
Acetylation of histones, as well as non-histone proteins, plays important roles in regulating various cellular processes. Dynamic… (More)
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Highly Cited
2000
Highly Cited
2000
Histone acetylation alters chromatin state by modifying lysines on histone and plays an important role in modulating gene… (More)
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