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Histamine N-Methyltransferase

Known as: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase, N-Methyltransferase, Histamine, Methyltransferase, Histamine 
An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to histamine, forming N-methylhistamine, the major metabolite of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Histamine clearance is an essential process for avoiding excessive histaminergic neuronal activity. Previous studies using… Expand
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Highly Cited
2012
Highly Cited
2012
Earlier studies showed neuronal histamine production in the hypothalamic tuberomamillary nucleus to be unchanged in Parkinson's… Expand
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Review
2007
Review
2007
Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation… Expand
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2005
2005
In mammals, histamine action is terminated through metabolic inactivation by histamine N-methyltransferase (HNMT) and diamine… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Histamine plays important biological roles in cell-to-cell communication; it is a mediator in allergic responses, a… Expand
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Highly Cited
2000
Highly Cited
2000
Histamine is involved in the pathophysiology of asthma, and histamine N-methyltransferase (HNMT) plays the dominant role in… Expand
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Review
1999
Review
1999
Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic… Expand
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Highly Cited
1998
Highly Cited
1998
Histamine N-methyltransferase (HNMT) catalyzes a major pathway in histamine metabolism. Levels of HNMT activity in humans are… Expand
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Highly Cited
1985
Highly Cited
1985
When [14C]histamine was administered orally to rats, an average of 80% of the administered radioactivity was recovered in the… Expand
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Highly Cited
1972
Highly Cited
1972
— Microassays are described for histamine, histidine, and the activities of the enzymes histidine decarboxylase (EC 4.1.1.22) and… Expand
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