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Hexosaminidases

Known as: Hexosaminidase, Hexosaminidases [Chemical/Ingredient] 
Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and… Expand
National Institutes of Health

Related topics

Related topics

16 relations

Narrower (7)

1,4-beta-chitobiosidaseBETA-N-ACETYLHEXOSAMINIDASEGalactosaminidasesGlucosaminidases
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GangliosidosesIn BloodProcess of secretionantagonists & inhibitors
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Broader (1)

Glycoside Hydrolases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.
Lysosomal beta-hexosaminidase A (Hex A) is essential for the degradation of GM2 gangliosides in the central and peripheral… Expand
Highly Cited
2004
Highly Cited
2004
Pharmacological Enhancement of β-Hexosaminidase Activity in Fibroblasts from Adult Tay-Sachs and Sandhoff Patients*
Tay-Sachs and Sandhoff diseases are lysosomal storage disorders that result from an inherited deficiency of β-hexosaminidase A… Expand
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Highly Cited
2003
Highly Cited
2003
Detachment of Actinobacillus actinomycetemcomitans Biofilm Cells by an Endogenous β-Hexosaminidase Activity
ABSTRACT When cultured in broth, fresh clinical isolates of the gram-negative periodontal pathogen Actinobacillus… Expand
Highly Cited
2001
Highly Cited
2001
Crystallographic Evidence for Substrate-assisted Catalysis in a Bacterial β-Hexosaminidase*
β-Hexosaminidase, a family 20 glycosyl hydrolase, catalyzes the removal of β-1,4-linkedN-acetylhexosamine residues from… Expand
Highly Cited
2001
Highly Cited
2001
Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes
Rab27a activity is affected in several mouse models of human disease including Griscelli (ashen mice) and Hermansky-Pudlak… Expand
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Highly Cited
1994
Highly Cited
1994
Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.
Glycosylation of nuclear and cytoplasmic proteins by O-linked N-acetylglucosamine (O-GlcNAc) monosaccharides is an abundant… Expand
Highly Cited
1985
Highly Cited
1985
Evidence for two different active sites on human beta-hexosaminidase A. Interaction of GM2 activator protein with beta-hexosaminidase A.
Competition experiments were carried out on the hydrolysis of different substrates by beta-hexosaminidase A isolated from human… Expand
Highly Cited
1984
Highly Cited
1984
Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens.
  • U. Landegren
  • Journal of immunological methods
  • 1984
    • Corpus ID: 3554368
By using a chromogenic substrate for an ubiquitous lysosomal enzyme, hexosaminidase to estimate cell numbers, a sensitive and… Expand
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Highly Cited
1982
Highly Cited
1982
Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.
Anti-IgE-dependent activation of rat and human mast cells resulted in the preferential generation of the cyclooxygenase products… Expand
Highly Cited
1978
Highly Cited
1978
AB variant of infantile GM2 gangliosidosis: deficiency of a factor necessary for stimulation of hexosaminidase A-catalyzed degradation of ganglioside GM2 and glycolipid GA2.
Human kidney extracts heated to 60 degrees and devoid of hexosaminidase activity (2-acetamido-2-deoxy-beta-D-glucoside… Expand
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