Hexosaminidases

Known as: Hexosaminidase, Hexosaminidases [Chemical/Ingredient] 
Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and… (More)
National Institutes of Health

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Narrower (7)

1,4-beta-chitobiosidaseBETA-N-ACETYLHEXOSAMINIDASEGalactosaminidasesGlucosaminidases
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GangliosidosesIn BloodProcess of secretionantagonists & inhibitors
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Broader (1)

Glycoside Hydrolases

Papers overview

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Highly Cited
2004
Highly Cited
2004
Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients.
Tay-Sachs and Sandhoff diseases are lysosomal storage disorders that result from an inherited deficiency of beta-hexosaminidase A… (More)
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Highly Cited
2003
Highly Cited
2003
Detachment of Actinobacillus actinomycetemcomitans biofilm cells by an endogenous beta-hexosaminidase activity.
When cultured in broth, fresh clinical isolates of the gram-negative periodontal pathogen Actinobacillus actinomycetemcomitans… (More)
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Highly Cited
2001
Highly Cited
2001
Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
beta-Hexosaminidase, a family 20 glycosyl hydrolase, catalyzes the removal of beta-1,4-linked N-acetylhexosamine residues from… (More)
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Highly Cited
2001
Highly Cited
2001
Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes
Rab27a activity is affected in several mouse models of human disease including Griscelli (ashen mice) and Hermansky-Pudlak… (More)
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Highly Cited
1994
Highly Cited
1994
Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.
Glycosylation of nuclear and cytoplasmic proteins by O-linked N-acetylglucosamine (O-GlcNAc) monosaccharides is an abundant… (More)
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1985
1985
Evidence for two different active sites on human beta-hexosaminidase A. Interaction of GM2 activator protein with beta-hexosaminidase A.
Competition experiments were carried out on the hydrolysis of different substrates by beta-hexosaminidase A isolated from human… (More)
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Highly Cited
1984
Highly Cited
1984
Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens.
By using a chromogenic substrate for an ubiquitous lysosomal enzyme, hexosaminidase to estimate cell numbers, a sensitive and… (More)
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1983
1983
IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells
Mouse bone marrow-derived mast cells differentiated in vitro and sensitized with monoclonal IgE respond to antigen-initiated… (More)
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Highly Cited
1982
Highly Cited
1982
Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.
Anti-IgE-dependent activation of rat and human mast cells resulted in the preferential generation of the cyclooxygenase products… (More)
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Highly Cited
1978
Highly Cited
1978
AB variant of infantile GM2 gangliosidosis: deficiency of a factor necessary for stimulation of hexosaminidase A-catalyzed degradation of ganglioside GM2 and glycolipid GA2.
Human kidney extracts heated to 60 degrees and devoid of hexosaminidase activity (2-acetamido-2-deoxy-beta-D-glucoside… (More)
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