Hereditary Diffuse Gastric Cancer

Known as: Hereditary Diffuse Gastric Adenocarcinoma, GASTRIC CANCER, HEREDITARY DIFFUSE, HDGC 
An autosomal dominant inherited adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
IMPORTANCE E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting clinically defined hereditary diffuse… (More)
  • table 1
  • figure 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Review
2015
Review
2015
Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
2010
Highly Cited
2010
25-30% of families fulfilling the criteria for hereditary diffuse gastric cancer have germline mutations of the CDH1 (E-cadherin… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2010
Review
2010
Gastric cancer is one of the world's leading causes of cancer mortality. A small percentage of cases can be attributed to… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Germline CDH1 point or small frameshift mutations can be identified in 30-50% of hereditary diffuse gastric cancer (HDGC… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2007
Highly Cited
2007
CONTEXT Hereditary diffuse gastric cancer is caused by germline mutations in the epithelial cadherin (CDH1) gene and is… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • table 4
Is this relevant?
Review
2006
Review
2006
Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome defined by germline mutation of the E-cadherin gene (CDH-1… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The International Gastric Cancer Linkage Consortium (IGCLC) predicted that up to 25% of families fulfilling the criteria for… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
BACKGROUND & AIMS Germline mutations in CDH1 are known to cause hereditary diffuse gastric cancer (HDGC). Breast and colorectal… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Aberrant promoter methylation and the associated loss of gene expression is a common accompaniment of human cancers. Nonetheless… (More)
  • figure 1
  • figure 2
Is this relevant?