FAQ

Hepatocyte Growth Factor Activator, human

Known as: HGF Activator, Hepatocyte Growth Factor Activator, EC 3.4.21.- 
Hepatocyte growth factor activator (655 aa, ~71 kDa) is encoded by the human HGFAC gene. This protein is involved in the proteolysis of single-chain… (More)

Topic mentions per year

Topic mentions per year

1993-2017
0102019932017

Related topics

Related topics

11 relations
Enzyme GeneExtracellular SpaceHGFAC geneHydrolase Gene
(More)

Broader (1)

Serine Endopeptidases

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Hepatocyte Growth Factor Activator, human
Hydrolysis
Proteolysis
Liver parenchyma
Serine Endopeptidases
Extracellular Space

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer.
Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte growth factor (HGF) into its active form… (More)
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2007
2007
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is a Kunitz-type transmembrane serine protease inhibitor that forms… (More)
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Highly Cited
2006
Highly Cited
2006
A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1.
BACKGROUND Matriptase, a type II transmembrane serine protease is involved in angiogenesis, degradation of extracellular matrix… (More)
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2005
2005
Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells.
Activation of single-chain, latent matriptase, a type II transmembrane serine protease, depends on the weak proteolytic activity… (More)
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Highly Cited
2004
Highly Cited
2004
The hepatocyte growth factor regulatory factors in human breast cancer.
PURPOSE Hepatocyte growth factor (HGF) stimulates tumor cell-cell interactions, matrix adhesion, migration, invasion, and… (More)
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Highly Cited
2003
Highly Cited
2003
Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node…
Numerous studies have demonstrated that overexpression of Met, the hepatocyte growth factor(HGF) receptor, plays an important… (More)
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2000
2000
Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma.
Activation of hepatocyte growth factor/scatter factor (HGF/SF) in the extracellular milieu is a critical limiting step in the HGF… (More)
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Highly Cited
1997
Highly Cited
1997
Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor.
Hepatocyte growth factor (HGF) activator is a serine protease that is produced and secreted by the liver and circulates in the… (More)
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1997
1997
Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.
Hepatocyte growth factor (HGF) activator is a serine protease responsible for proteolytic activation of HGF in response to tissue… (More)
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1993
1993
Activation of the zymogen of hepatocyte growth factor activator by thrombin.
Hepatocyte growth factor activator (HGF activator) is a serine protease which converts single-chain HGF to the active two-chain… (More)
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