Hemoglobin SC Disease

Known as: Disease, SC, hemoglobin s-c disease, Hemoglobin SC Diseases 
A hemoglobinopathy that is considered a hybrid of sickle cell disease and hemoglobin C disease. Patients present with the symptoms of sickle cell… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1940-2017
05010015019402016

Papers overview

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2017
2017
BACKGROUND Stroke is a severe clinical disorder in sickle cell disease (SCD), and few studies have evaluated transcranial Doppler… (More)
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Highly Cited
2011
Highly Cited
2011
Persistence of human fetal hemoglobin (HbF, α(2)γ(2)) in adults lessens the severity of sickle cell disease (SCD) and the… (More)
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Highly Cited
2008
Highly Cited
2008
Sickle cell disease (SCD) is a debilitating monogenic blood disorder with a highly variable phenotype characterized by severe… (More)
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Highly Cited
2004
Highly Cited
2004
High frequency of erythrocyte (red blood cell [RBC]) genetic disorders such as sickle cell trait, thalassemia trait, homozygous… (More)
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2000
2000
The incidence of functional asplenia in sickle-hemoglobin C (SC) disease has not been defined, and the use of prophylactic… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND In a previous open-label study of hydroxyurea therapy, the synthesis of fetal hemoglobin increased in most patients… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Information on life expectancy and risk factors for early death among patients with sickle cell disease (sickle cell… (More)
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Highly Cited
1992
Highly Cited
1992
Patients with sickle cell anemia were treated with daily doses of hydroxyurea, to assess pharmacokinetics, toxicity, and increase… (More)
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Highly Cited
1991
Highly Cited
1991
BACKGROUND AND METHODS Acute episodes of pain are the principal symptom of sickle cell disease, but little is known about the… (More)
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Highly Cited
1989
Highly Cited
1989
Denaturing gradient gel electrophoresis (DGGE) can be used to distinguish two DNA molecules that differ by as little as a single… (More)
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