Hemicholinium 3

Known as: Hemicholinium, Hemicholinium 3 [Chemical/Ingredient], Morpholinium, 2,2'-(1,1'-biphenyl)-4,4'-diylbis(2-hydroxy-4,4-dimethyl)-, dibromide 
A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the… (More)

Topic mentions per year

Topic mentions per year

1956-2017
0204019562016

Papers overview

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2006
2006
CF-1 male mice were trained in an inhibitory avoidance task using a high footshock (1,2 mA, 50 Hz, 1 sec) in order to reduce the… (More)
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2004
2004
The immediate post-training i.c.v. administration of hemicholinium-3 (HC-3) (1 microg), a specific inhibitor of the high-affinity… (More)
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2003
2003
Synthesis of acetylcholine depends on the plasma membrane uptake of choline by a high affinity choline transporter (CHT1… (More)
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Highly Cited
2003
Highly Cited
2003
It is well established that small cell lung carcinomas (SCLCs) express receptors for acetylcholine (ACh) and that stimulation of… (More)
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2001
2001
In cholinergic neurons, a specific requirement for precursor choline in the biosynthesis of acetylcholine (ACh) is thought to be… (More)
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2000
2000
Under many physiological circumstances, Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high-affinity choline… (More)
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1997
1997
In a search for behavioral, neuroanatomical, and metabolic characteristics of Alzheimer's disease that may result from… (More)
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Highly Cited
1992
Highly Cited
1992
Degeneration of the cholinergic magnocellular neurons in the basal forebrain and their cortical projections is a major feature of… (More)
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1983
1983
Sodium-dependent, hemicholinium-sensitive choline transport was measured in purified synaptosomes prepared from fresh necropsy… (More)
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1982
1982
1 The site (i.e. peripheral or central) of the toxicity produced by hemicholinium-3 in mice was investigated. 2 Hemicholinium-3… (More)
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