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HSXIAPAF1 protein, human

Known as: XIAP-Associated Factor 1, XAF1 protein, human, XIAP-associated factor 1, human 
XIAP-associated factor 1 (301 aa, ~35 kDa) is encoded by the human XAF1 gene. This protein plays a role in the regulation of apoptosis.
National Institutes of Health

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Related topics

9 relations
ApoptosisApoptosis PromoterGenes, RegulatorPositive Regulation of Apoptosis

Broader (1)

Neoplasm Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
TGF-β1 protects colon tumor cells from apoptosis through XAF1 suppression.
Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that functions as a growth suppressor in normal epithelial… 
2017
2017
Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome
XAF1 (X-linked inhibitor of apoptosis (XIAP)-associated factor 1) is a tumor suppressor that counteracts the anti-apoptotic… 
2015
2015
XIAP associated factor 1 (XAF1) represses expression of X-linked inhibitor of apoptosis protein (XIAP) and regulates invasion, cell cycle, apoptosis, and cisplatin sensitivity of ovarian carcinoma…
BACKGROUND X-linked inhibitor of apoptosis protein (XIAP) associated factor 1 (XAF1) exhibits aberrantly low or absent expression… 
2015
2015
A novel splice variant of XIAP-associated factor 1 (XAF1) is expressed in peripheral blood containing gastric cancer-derived circulating tumor cells
BackgroundXIAP-associated factor 1 (XAF1) is ubiquitously expressed in normal tissues, but its suppression in cancer cells is… 
2013
2013
ROS and ERK1/2-mediated caspase-9 activation increases XAF1 expression in dexamethasone-induced apoptosis of EBV-transformed B cells
Dexamethasone (Dex) inhibits the growth of diverse types of cancer cells and is utilized clinically for the therapy of… 
2012
2012
XIAP‐associated factor 1 (XAF1), a novel target of p53, enhances p53‐mediated apoptosis via post‐translational modification
The role of X chromosome‐linked inhibitor of apoptosis protein (XIAP)‐associated factor 1 (XAF1) in mediating apoptosis has been… 
2012
2012
Domain organization of XAF1 and the identification and characterization of XIAPRING‐binding domain of XAF1
X‐linked inhibitor of apoptosis protein (XIAP)‐associated factor 1 (XAF1) has been implicated as a novel tumor suppressor, which… 
2009
2009
XAF1 mRNA expression improves progression-free and overall survival for patients with advanced bladder cancer treated with neoadjuvant chemotherapy.
Highly Cited
2007
Highly Cited
2007
XAF1 Mediates Tumor Necrosis Factor-α-induced Apoptosis and X-linked Inhibitor of Apoptosis Cleavage by Acting through the Mitochondrial Pathway*
Tumor necrosis factor-α (TNF-α) and Fas ligand induce apoptosis by interacting with their corresponding membrane-bound death… 
1993
1993
ZAP-1 DNA binding activity is first detected at the onset of zona pellucida gene expression in embryonic mouse oocytes.
ZAP-1 (zona pellucida gene activating protein-1) is a putative transcription factor controlling the oocyte-specific expression of… 
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