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Leydig cells play a pivotal function in the synthesis of a male sex steroid, testosterone. The ability of the steroid production… Expand HSD3B catalyzes the synthesis of δ4 steroids such as progesterone in the adrenals and gonads. Individuals lacking HSD3B2 activity… Expand The aim of the study was to investigate the in vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on steroid hormone… Expand So where is the excitement in the study of steroidogenesis? It is pretty well cut-and-dried; after all, 17b-estradiol is the same… Expand Testosterone-producing adult Leydig cells emerge at puberty, and most persist thereafter without turning over. But where do the… Expand To test our hypothesis that the hormonal phenotype of mild 3beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in… Expand 3beta-hydroxysteroid dehydrogenases (HSD3Bs), encoded by the HSD3B gene family at 1p13, have long been hypothesized to have a… Expand Mutations in HSD3B2, the gene for 3beta-hydroxysteroid dehydrogenase type II (3beta-HSD II) have been detected and activities… Expand The enzyme 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3 beta-HSD) catalyses an essential step in the… Expand Polymorphism: Sequencing of amplified exon 4(1) identified a single base pair substitution at position 1100 in the coding… Expand