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HPC1 gene

Known as: HPC1, hereditary prostate cancer 1 
 
National Institutes of Health

Related topics

Related topics

3 relations
ELAC2 protein, humanPROSTATE CANCER, HEREDITARY, X-LINKED 1Prostate cancer, familial

Papers overview

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Review
2011
Review
2011
New insights into the role of RNase L in innate immunity.
The interferon (IFN)-inducible 2'-5'-oligoadenylate synthetase (OAS)/RNase L pathway blocks infections by some types of viruses… Expand
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Highly Cited
2007
Highly Cited
2007
Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.
OBJECTIVES Polycomb group (PcG) proteins are involved in maintenance of cell identity and proliferation. The protein EZH2 is… Expand
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2004
2004
HPC1/RNASEL Mediates Apoptosis of Prostate Cancer Cells Treated with 2′,5′-Oligoadenylates, Topoisomerase I Inhibitors, and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand
The hereditary prostate cancer 1 (HPC1) allele maps to the RNASEL gene encoding a protein (RNase L) implicated in the antiviral… Expand
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Highly Cited
2004
Highly Cited
2004
Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines.
Human Polycomb-group (PcG) genes play a crucial role in the regulation of embryonic development and regulation of the cell cycle… Expand
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Review
2003
Review
2003
Prostate cancer susceptibility genes: lessons learned and challenges posed.
In most developed countries, prostate cancer is the most frequently diagnosed malignancy in men. The extent to which the marked… Expand
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Highly Cited
2002
Highly Cited
2002
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1
Although prostate cancer is the most common non-cutaneous malignancy diagnosed in men in the United States, little is known about… Expand
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Highly Cited
2002
Highly Cited
2002
Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.
The RNASEL gene (2',5'-oligoisoadenylate-synthetase dependent) encodes a ribonuclease that mediates the antiviral and apoptotic… Expand
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Highly Cited
2002
Highly Cited
2002
Germline Mutations in the Ribonuclease L Gene in Families Showing Linkage With HPC1
 
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Highly Cited
1997
Highly Cited
1997
Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus.
CONTEXT Approximately 9% of prostate cancer cases have been estimated to result from inheritance of mutated prostate cancer… Expand
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1997
1997
Early age at diagnosis in families providing evidence of linkage to the hereditary prostate cancer locus (HPC1) on chromosome 1.
In a recent study of 91 families having at least three first degree relatives with prostate cancer, we reported the localization… Expand
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