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HPC1 gene

Known as: HPC1, hereditary prostate cancer 1 
 
National Institutes of Health

Related topics

Related topics

3 relations
ELAC2 protein, humanPROSTATE CANCER, HEREDITARY, X-LINKED 1Prostate cancer, familial

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
New insights into the role of RNase L in innate immunity.
The interferon (IFN)-inducible 2'-5'-oligoadenylate synthetase (OAS)/RNase L pathway blocks infections by some types of viruses… Expand
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Highly Cited
2007
Highly Cited
2007
Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.
OBJECTIVES Polycomb group (PcG) proteins are involved in maintenance of cell identity and proliferation. The protein EZH2 is… Expand
Review
2003
Review
2003
Prostate cancer susceptibility genes: lessons learned and challenges posed.
In most developed countries, prostate cancer is the most frequently diagnosed malignancy in men. The extent to which the marked… Expand
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Highly Cited
2002
Highly Cited
2002
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1
Although prostate cancer is the most common non-cutaneous malignancy diagnosed in men in the United States, little is known about… Expand
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Highly Cited
2002
Highly Cited
2002
Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.
The RNASEL gene (2',5'-oligoisoadenylate-synthetase dependent) encodes a ribonuclease that mediates the antiviral and apoptotic… Expand
Highly Cited
2000
Highly Cited
2000
A genetic epidemiological study of hereditary prostate cancer (HPC) in Finland: frequent HPCX linkage in families with late-onset disease.
Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPC1 at 1q24-q25 (OMIM #601518… Expand
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Highly Cited
1998
Highly Cited
1998
Evidence for a prostate cancer susceptibility locus on the X chromosome.
Over 200,000 new prostate cancer cases are diagnosed in the United States each year, accounting for more than 35% of all cancer… Expand
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Highly Cited
1997
Highly Cited
1997
Early age at diagnosis in families providing evidence of linkage to the hereditary prostate cancer locus (HPC1) on chromosome 1.
In a recent study of 91 families having at least three first degree relatives with prostate cancer, we reported the localization… Expand
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Highly Cited
1997
Highly Cited
1997
Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus
Context. —Approximately 9% of prostate cancer cases have been estimated to result from inheritance of mutated prostate cancer… Expand
Highly Cited
1992
Highly Cited
1992
Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1.
A monoclonal antibody (mAb), HPC-1, labels the plasma membrane of the amacrine cell soma and inner plexiform layer in rat retina… Expand
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