HPC1 gene

The interferon (IFN)-inducible 2'-5'-oligoadenylate synthetase (OAS)/RNase L pathway blocks infections by some types of viruses… (More)

The 2-5A/RNase L pathway is one of the first cellular defences against viruses. RNase L is an unusual endoribonuclease which… (More)

In many developed countries, prostate cancer is the most frequently diagnosed malignancy in men. The extent to which the marked… (More)

Confirmation of linkage and estimation of the proportion of families who are linked in large independent datasets is essential to… (More)

Several hereditary disease loci have been genetically mapped to the chromosome 1q24-q31 interval, including the hereditary… (More)

Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPC1 at 1q24-q25 (OMIM #601518… (More)

Prostate cancer clusters in some families, and an estimated 5%-10% of all cases are estimated to result from inheritance of… (More)

CONTEXT Approximately 9% of prostate cancer cases have been estimated to result from inheritance of mutated prostate cancer… (More)

In a recent study of 91 families having at least three first degree relatives with prostate cancer, we reported the localization… (More)

BACKGROUND Recent recognition that a predisposition to prostate cancer can be inherited has led to a search for specific genes… (More)